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IL-8 as a circulating cytokine: induction by recombinant tumour necrosis factor-alpha

Record type: Article

Tumour necrosis factor-alpha (TNF-alpha) is a pivotal cytokine at the centre of a cascade of cytokines and inflammatory mediators which modulate the host response to infection and trauma, and in particular the metabolic changes resulting in shock and subsequent multi-organ failure. The cytokine IL-8--predominantly an activator and chemotactic factor for circulating polymorphonuclear neutrophil leucocytes--is produced in response to TNF-alpha in vitro, and high circulating levels of IL-8 are found in septic primates. We have studied the release of IL-8 into the circulation of subjects with chronic hepatitis B undergoing a 10 week pilot trial of recombinant TNF-alpha (rTNF-alpha) therapy in doses of 15-100 micrograms/m2. A marked dose-dependent increase in plasma IL-8 levels was seen commencing at 30-60 min after the start of rTNF-alpha infusion and peaking between 2 and 3 h (mean peak level 4300 ng/l). The temporal pattern of IL-8 production exactly echoed that of IL-6, another component of the cytokine cascade, but peak plasma levels of IL-8 were up to 17 times higher than those of IL-6. This study confirms in vitro data suggesting that IL-8 is a component of the acute circulating cytokine cascade with a potential role in the modulation of the acute immune and metabolic response to infection and trauma.

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Citation

Sheron, N. and Williams, R. (1992) IL-8 as a circulating cytokine: induction by recombinant tumour necrosis factor-alpha Clinical and Experimental Immunology, 89, (1), pp. 100-103.

More information

Published date: July 1992

Identifiers

Local EPrints ID: 154577
URI: http://eprints.soton.ac.uk/id/eprint/154577
ISSN: 0009-9104
PURE UUID: 54dbed52-c3fe-4cb0-8cda-590205f1dc12
ORCID for N. Sheron: ORCID iD orcid.org/0000-0001-5232-8292

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Date deposited: 14 Jul 2010 15:37
Last modified: 18 Jul 2017 12:46

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