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Increased production of tumour necrosis factor alpha in chronic hepatitis B virus infection

Sheron, N., Lau, J., Daniels, H.M., Goka, J., Eddleston, A., Alexander, G.J.M. and Williams, R. (1991) Increased production of tumour necrosis factor alpha in chronic hepatitis B virus infection Journal of Hepatology, 12, (2), pp. 241-245. (doi:10.1016/0168-8278(91)90945-8).

Record type: Article


Plasma tumour necrosis factor alpha (TNF) and in-vitro TNF production by peripheral blood mononuclear cells (PBMC) were studied in 22 HBsAg seropositive patients and compared with 23 normal and 10 disease controls. Plasma TNF and unstimulated TNF production correlated (Rs = 0.55, P = 0.012) and were significantly elevated in HBsAg and HBeAg seropositive patients (p < 0.001, P = 0.006) compared with normal controls. TNF production was also elevated in these patients when PBMC were stimulated with interferon-? (p < 0.05) or LPS (p = 0.035). Plasma TNF and TNF production in HBsAg anti-HBe seropositive subjects were not elevated. TNF production in unstimulated cells correlated with serum HBV DNA level (R = 0.53, P = 0.02) but not with serum aspartate transaminase (AST) or histological activity. It is concluded that PBMC are activated to produce TNF both spontaneously and in response to second stimuli in chronic hepatitis B virus infection and that this activity is related to the presence of viral replication.

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Published date: 1991


Local EPrints ID: 154589
ISSN: 0168-8278
PURE UUID: 1d5838de-1dd8-4760-803d-ee9873248251
ORCID for N. Sheron: ORCID iD

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Date deposited: 14 Jul 2010 16:41
Last modified: 18 Jul 2017 12:46

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Author: N. Sheron ORCID iD
Author: J. Lau
Author: H.M. Daniels
Author: J. Goka
Author: A. Eddleston
Author: G.J.M. Alexander
Author: R. Williams

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