Dose dependant increase in plasma interleukin 6 after recombinant tumour necrosis factor infusion in humans

Sheron, N., Lau, J., Hofmann, J., Williams, R. and Alexander, G.J.M. (1990) Dose dependant increase in plasma interleukin 6 after recombinant tumour necrosis factor infusion in humans. Clinical and Experimental Immunology, 82 (3), 427-428. (doi:10.1111/j.1365-2249.1990.tb05465.x).

Abstract

Several studies have shown that the cytokine interleukin-6 (IL-6) is produced in response to tumour necrosis factor (TNF) in vitro. This study examines the in vivo relation between these two cytokines with assays of plasma IL-6 and TNF levels in subjects with chronic hepatitis B undergoing immunomodulatory therapy with recombinant TNF (rTNF). Plasma IL-6 was detected from 20 min after rTNF infusion with levels peaking after 2-3 h and levels correlated with the dose of rTNF administered (r = 0.67, P = 0.004). Peak levels of IL-6 (mean 295, range 266-297 ng/l) were lower than those seen in certain disease states despite the very high peak levels of rTNF (mean 11,750, range 5623-18,620 ng/l). These findings suggest that the very high levels of IL-6 found in certain disease states are not purely the result of circulating TNF. Other factors such as endotoxin or other cytokines may also play a role in determining levels of plasma IL-6.

This record has no associated files available for download.

Contributors

Download statistics