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Dose dependant increase in plasma interleukin 6 after recombinant tumour necrosis factor infusion in humans

Dose dependant increase in plasma interleukin 6 after recombinant tumour necrosis factor infusion in humans
Dose dependant increase in plasma interleukin 6 after recombinant tumour necrosis factor infusion in humans
Several studies have shown that the cytokine interleukin-6 (IL-6) is produced in response to tumour necrosis factor (TNF) in vitro. This study examines the in vivo relation between these two cytokines with assays of plasma IL-6 and TNF levels in subjects with chronic hepatitis B undergoing immunomodulatory therapy with recombinant TNF (rTNF). Plasma IL-6 was detected from 20 min after rTNF infusion with levels peaking after 2-3 h and levels correlated with the dose of rTNF administered (r = 0.67, P = 0.004). Peak levels of IL-6 (mean 295, range 266-297 ng/l) were lower than those seen in certain disease states despite the very high peak levels of rTNF (mean 11,750, range 5623-18,620 ng/l). These findings suggest that the very high levels of IL-6 found in certain disease states are not purely the result of circulating TNF. Other factors such as endotoxin or other cytokines may also play a role in determining levels of plasma IL-6.
0009-9104
427-428
Sheron, N.
eec47bea-1b5b-4d6e-b949-f6c25ab16f09
Lau, J.
110111bb-650d-4542-b129-19539b7b594b
Hofmann, J.
898f4b60-38b0-4a96-81fb-38a1570abf8a
Williams, R.
49181762-00c1-4043-9247-a9bcddbd04f7
Alexander, G.J.M.
33154574-e14c-4ac3-ae5e-f5983b531348
Sheron, N.
eec47bea-1b5b-4d6e-b949-f6c25ab16f09
Lau, J.
110111bb-650d-4542-b129-19539b7b594b
Hofmann, J.
898f4b60-38b0-4a96-81fb-38a1570abf8a
Williams, R.
49181762-00c1-4043-9247-a9bcddbd04f7
Alexander, G.J.M.
33154574-e14c-4ac3-ae5e-f5983b531348

Sheron, N., Lau, J., Hofmann, J., Williams, R. and Alexander, G.J.M. (1990) Dose dependant increase in plasma interleukin 6 after recombinant tumour necrosis factor infusion in humans. Clinical and Experimental Immunology, 82 (3), 427-428.

Record type: Article

Abstract

Several studies have shown that the cytokine interleukin-6 (IL-6) is produced in response to tumour necrosis factor (TNF) in vitro. This study examines the in vivo relation between these two cytokines with assays of plasma IL-6 and TNF levels in subjects with chronic hepatitis B undergoing immunomodulatory therapy with recombinant TNF (rTNF). Plasma IL-6 was detected from 20 min after rTNF infusion with levels peaking after 2-3 h and levels correlated with the dose of rTNF administered (r = 0.67, P = 0.004). Peak levels of IL-6 (mean 295, range 266-297 ng/l) were lower than those seen in certain disease states despite the very high peak levels of rTNF (mean 11,750, range 5623-18,620 ng/l). These findings suggest that the very high levels of IL-6 found in certain disease states are not purely the result of circulating TNF. Other factors such as endotoxin or other cytokines may also play a role in determining levels of plasma IL-6.

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Published date: 1990

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Local EPrints ID: 154615
URI: https://eprints.soton.ac.uk/id/eprint/154615
ISSN: 0009-9104
PURE UUID: 16419091-c416-4b13-b2cd-756bb3269d0c

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Date deposited: 14 Jul 2010 16:44
Last modified: 26 Oct 2017 09:54

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