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Morphological differences between beta2-microglobulin in fibrils and inclusion bodies

Taylor, Garrick F., Wood, Stephen P., Moers, Karsten, Glaubitz, Clemens, Werner, Jorn M. and Williamson, Phillip T.F. (2011) Morphological differences between beta2-microglobulin in fibrils and inclusion bodies ChemBioChem, 12, (4), pp. 556-558. (doi:10.1002/cbic.201000582).

Record type: Article

Abstract

Over expression of proteins in E. coli frequently results in the production of inclusion bodies. Although ?2-microglobulin frequently forms fibrillar structures, our studies reveal significant differences between the protein in fibrils and inclusion bodies. This suggests that the formation of fibrils in inclusion bodies is dependent on the propensity of the protein to form fibrillar structures.

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More information

Published date: 26 January 2011
Keywords: amyloid fibrils, inclusion bodies, microglobulin, protein folding, solid-state nmr spectroscopy

Identifiers

Local EPrints ID: 154965
URI: http://eprints.soton.ac.uk/id/eprint/154965
ISSN: 1439-4227
PURE UUID: 238541f6-1f4a-4e51-ba41-b19fbfa88583
ORCID for Jorn M. Werner: ORCID iD orcid.org/0000-0002-4712-1833
ORCID for Phillip T.F. Williamson: ORCID iD orcid.org/0000-0002-0231-8640

Catalogue record

Date deposited: 08 Feb 2011 09:15
Last modified: 18 Jul 2017 12:46

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Contributors

Author: Garrick F. Taylor
Author: Stephen P. Wood
Author: Karsten Moers
Author: Clemens Glaubitz
Author: Jorn M. Werner ORCID iD

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