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Cloning and expression analysis of drosophila melanogaster extracellular Cu Zn SOD reveals sex specific variation

Blackney, Michael J., Shepherd, D. and Parker, J.D. (2010) Cloning and expression analysis of drosophila melanogaster extracellular Cu Zn SOD reveals sex specific variation Journal of Insect Molecular Biology

Record type: Article

Abstract

Abstract: The superoxide dismutase (SOD) family of enzymes regulate reactive oxygen species by scavenging superoxide. In Drosophila homologues of two of the mammalian SODs, the intracellular (Sod1) and mitochondrial (Sod2) SODs, have been studied extensively indicating a link between SOD and ageing. Recently the sequence of a third Sod gene, homologous to both mammalian (Sod3) and C. elegans (Sod4) extracellular Sod, was identified in Drosophila and is also predicted to locate extracellularly (Sod3). We have cloned and sequenced this gene, identifying two gene products formed by alternative splicing. Here we report differential sex specific Sod3 expression patterns along with validation of a Sod3 hypomorph mutant. Furthermore, we indicate a functional role of Sod3 in protecting against H2O2 induced oxidative stress.

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Published date: 2010

Identifiers

Local EPrints ID: 154969
URI: http://eprints.soton.ac.uk/id/eprint/154969
ISSN: 0962-1075
PURE UUID: 12df8dd1-0e5e-4d35-8e92-fcc064d7cea2

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Date deposited: 26 May 2010 14:03
Last modified: 18 Jul 2017 12:46

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Contributors

Author: Michael J. Blackney
Author: D. Shepherd
Author: J.D. Parker

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