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Development of the European organisation for research and treatment of cancer quality of life questionnaire module for older people with cancer: the EORTC QLQ-ELD15

Development of the European organisation for research and treatment of cancer quality of life questionnaire module for older people with cancer: the EORTC QLQ-ELD15
Development of the European organisation for research and treatment of cancer quality of life questionnaire module for older people with cancer: the EORTC QLQ-ELD15
Background and aim

There is a lack of instruments that focus on the specific health-related quality of life (HRQOL) issues that affect older people with cancer. The aim of this study was to develop a HRQOL questionnaire module to supplement the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire, the EORTC QLQ-C30 for older (>70 years) patients with cancer.

Methods

Phases 1–3 were conducted in seven countries following modified EORTC Quality of Life Group guidelines for module development. Phase 1: potentially relevant issues were identified by a systematic literature review, a questionnaire survey of 17 multi-disciplinary health professionals and two rounds of qualitative interviews. The first round included 9 patients aged >70. The second round was a comparative series of interviews with 49 patients >70 years with a range of cancer diagnoses and 40 patients aged 50–69 years matched for gender and disease site. In Phase 2 the issues were formulated into a long provisional item list. This was administered in Phase 3 together with the QLQ-C30 to two further groups of cancer patients aged >70 (n = 97) or 50–69 years (n = 85) to determine the importance, relevance and acceptability of each item. Redundant and duplicate items were removed; issues specific to the older group were selected for the final questionnaire.

Results

In Phase 1, 75 issues were identified. These were reduced in Phase 2 to create a 45 item provisional list. Phase 3 testing of the provisional list led to the selection of 15 items with good range of response, high scores of importance and relevance in the older patients. This resulted in the EORTC QLQ-ELD15, containing five conceptually coherent scales (functional independence, relationships with family and friends, worries about the future, autonomy and burden of illness).

Conclusion

The EORTC QLQ-ELD15 in combination with the EORTC QLQ-C30 is ready for large-scale validation studies, and will assess HRQOL issues of most relevance and concern for older people with cancer across a wide range of cancer sites and treatment stages.
health-related quality of life, EORTC QLQ-C30, elderly, neoplasm
0959-8049
2242-2252
Johnson, Colin
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Fitzsimmons, Deborah
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Gilbert, Jacqueline
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Arrarras, Juan-Ignacio
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Hammerlid, Eva
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Bredart, Anne
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Ozmen, Mahir
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Dilektasli, Evren
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Coolbrandt, Anne
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Kenis, Cindy
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Young, Teresa
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Chow, Edward
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Venkitaraman, Ramachandran
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Howse, Frances
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George, Steve
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O'Connor, Steve
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Yadegarfar, Ghasem
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EORTC Quality of Life Group
Johnson, Colin
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a
Fitzsimmons, Deborah
4e282651-162f-48f0-bbf7-190c265279f2
Gilbert, Jacqueline
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Arrarras, Juan-Ignacio
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Hammerlid, Eva
43901291-21e1-42ac-87b2-4c0de04b6a79
Bredart, Anne
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Ozmen, Mahir
69ae7c8d-8447-4fcd-ba72-87f7fa62e70a
Dilektasli, Evren
9e2effd2-5e27-4213-b2d2-da148314f0ff
Coolbrandt, Anne
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Kenis, Cindy
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Young, Teresa
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Chow, Edward
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Venkitaraman, Ramachandran
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Howse, Frances
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George, Steve
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O'Connor, Steve
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Yadegarfar, Ghasem
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Johnson, Colin, Fitzsimmons, Deborah, Gilbert, Jacqueline, Arrarras, Juan-Ignacio, Hammerlid, Eva, Bredart, Anne, Ozmen, Mahir, Dilektasli, Evren, Coolbrandt, Anne, Kenis, Cindy, Young, Teresa, Chow, Edward, Venkitaraman, Ramachandran, Howse, Frances, George, Steve, O'Connor, Steve and Yadegarfar, Ghasem , EORTC Quality of Life Group (2010) Development of the European organisation for research and treatment of cancer quality of life questionnaire module for older people with cancer: the EORTC QLQ-ELD15. European Journal of Cancer, 46 (12), 2242-2252. (doi:10.1016/j.ejca.2010.04.014).

Record type: Article

Abstract

Background and aim

There is a lack of instruments that focus on the specific health-related quality of life (HRQOL) issues that affect older people with cancer. The aim of this study was to develop a HRQOL questionnaire module to supplement the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire, the EORTC QLQ-C30 for older (>70 years) patients with cancer.

Methods

Phases 1–3 were conducted in seven countries following modified EORTC Quality of Life Group guidelines for module development. Phase 1: potentially relevant issues were identified by a systematic literature review, a questionnaire survey of 17 multi-disciplinary health professionals and two rounds of qualitative interviews. The first round included 9 patients aged >70. The second round was a comparative series of interviews with 49 patients >70 years with a range of cancer diagnoses and 40 patients aged 50–69 years matched for gender and disease site. In Phase 2 the issues were formulated into a long provisional item list. This was administered in Phase 3 together with the QLQ-C30 to two further groups of cancer patients aged >70 (n = 97) or 50–69 years (n = 85) to determine the importance, relevance and acceptability of each item. Redundant and duplicate items were removed; issues specific to the older group were selected for the final questionnaire.

Results

In Phase 1, 75 issues were identified. These were reduced in Phase 2 to create a 45 item provisional list. Phase 3 testing of the provisional list led to the selection of 15 items with good range of response, high scores of importance and relevance in the older patients. This resulted in the EORTC QLQ-ELD15, containing five conceptually coherent scales (functional independence, relationships with family and friends, worries about the future, autonomy and burden of illness).

Conclusion

The EORTC QLQ-ELD15 in combination with the EORTC QLQ-C30 is ready for large-scale validation studies, and will assess HRQOL issues of most relevance and concern for older people with cancer across a wide range of cancer sites and treatment stages.

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More information

Published date: August 2010
Keywords: health-related quality of life, EORTC QLQ-C30, elderly, neoplasm

Identifiers

Local EPrints ID: 155289
URI: http://eprints.soton.ac.uk/id/eprint/155289
ISSN: 0959-8049
PURE UUID: ea081b2d-1491-49ca-b080-f94c1f943b38

Catalogue record

Date deposited: 27 May 2010 13:08
Last modified: 09 Jan 2022 08:26

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Contributors

Author: Colin Johnson
Author: Deborah Fitzsimmons
Author: Jacqueline Gilbert
Author: Juan-Ignacio Arrarras
Author: Eva Hammerlid
Author: Anne Bredart
Author: Mahir Ozmen
Author: Evren Dilektasli
Author: Anne Coolbrandt
Author: Cindy Kenis
Author: Teresa Young
Author: Edward Chow
Author: Ramachandran Venkitaraman
Author: Frances Howse
Author: Steve George
Author: Steve O'Connor
Author: Ghasem Yadegarfar
Corporate Author: EORTC Quality of Life Group

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