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Is karyotyping couples experiencing recurrent miscarriage worth the cost?

Is karyotyping couples experiencing recurrent miscarriage worth the cost?
Is karyotyping couples experiencing recurrent miscarriage worth the cost?
Karyotyping couples that have had recurrent miscarriages detects balanced rearrangements in carrier parents who can be offered prenatal cytogenetic analysis to prevent the birth of a subsequent child with an unbalanced rearrangement. In four UK centres, over periods of 5–30 years, balanced rearrangements were found in 406 out of 20 432 parents that had experienced miscarriage (1.9%), but only four unbalanced rearrangements were found after referral for prenatal diagnosis because of a balanced parental translocation ascertained for recurrent miscarriages. At an estimated cost of £3–4 million, these data raise doubts about the cost effectiveness of current policies on the routine karyotyping of couples experiencing repeated miscarriages.

cost effectiveness, karyotyping, policy, prevention, recurrent miscarriage, unbalanced karyotypes
1470-0328
885-888
Barber, John
4785a6e4-bd63-4230-ab61-41a0ae12c761
Cockwell, A.E.
93580166-ddfd-4522-9b18-1919fd983d4d
Grant, E.
a2b22fe5-e95a-4c9d-9689-76498ec843d7
Williams, S.
762dd529-2acb-40b8-acf3-e3488eec8506
Dunn, R.
3f3fd22e-accb-4e3a-a6d1-3420ce138832
Ogilvie, C.M.
4bb3059f-3593-4d29-98b1-93264725f45a
Barber, John
4785a6e4-bd63-4230-ab61-41a0ae12c761
Cockwell, A.E.
93580166-ddfd-4522-9b18-1919fd983d4d
Grant, E.
a2b22fe5-e95a-4c9d-9689-76498ec843d7
Williams, S.
762dd529-2acb-40b8-acf3-e3488eec8506
Dunn, R.
3f3fd22e-accb-4e3a-a6d1-3420ce138832
Ogilvie, C.M.
4bb3059f-3593-4d29-98b1-93264725f45a

Barber, John, Cockwell, A.E., Grant, E., Williams, S., Dunn, R. and Ogilvie, C.M. (2010) Is karyotyping couples experiencing recurrent miscarriage worth the cost? BJOG: An International Journal of Obstetrics & Gynaecology, 117 (7), 885-888. (doi:10.1111/j.1471-0528.2010.02566.x).

Record type: Article

Abstract

Karyotyping couples that have had recurrent miscarriages detects balanced rearrangements in carrier parents who can be offered prenatal cytogenetic analysis to prevent the birth of a subsequent child with an unbalanced rearrangement. In four UK centres, over periods of 5–30 years, balanced rearrangements were found in 406 out of 20 432 parents that had experienced miscarriage (1.9%), but only four unbalanced rearrangements were found after referral for prenatal diagnosis because of a balanced parental translocation ascertained for recurrent miscarriages. At an estimated cost of £3–4 million, these data raise doubts about the cost effectiveness of current policies on the routine karyotyping of couples experiencing repeated miscarriages.

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More information

Published date: June 2010
Keywords: cost effectiveness, karyotyping, policy, prevention, recurrent miscarriage, unbalanced karyotypes

Identifiers

Local EPrints ID: 155705
URI: https://eprints.soton.ac.uk/id/eprint/155705
ISSN: 1470-0328
PURE UUID: 0398397c-8d20-4340-971a-d359d1574175

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Date deposited: 28 May 2010 11:52
Last modified: 09 Feb 2018 17:31

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