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Individually addressable microelectrode array for monitoring oxygen and nitric oxide release

Patel, Bhavik Anil, Arundell, Martin, Quek, Ruben G.W., Harvey, Severin L.R., Ellis, Ian R., Florence, Margaret M., Cass, Anthony E.G., Schor, Ana M. and O'Hare, Danny (2008) Individually addressable microelectrode array for monitoring oxygen and nitric oxide release Analytical and Bioanalytical Chemistry, 390, (5), pp. 1379-1387. (doi:10.1007/s00216-007-1803-0).

Record type: Article


We have fabricated a six individual addressable gold working electrode microarray. The device is wirebonded to an eight-pin DIL package that can be easily interconnected to an external multi-channel potentiostat. A polyion complex film coating on the electrode surface provides a suitable coating for the growth of cells. The responses of oxygen and nitric oxide were assessed on uncoated and coated devices using electroanalytical methods. The film coating reduced the diffusion current by approximately 20% in both cases. No changes in the electrochemical mechanism were observed. Simultaneous recordings were obtained for 2 h in the presence of the cells, thus the device is stable for the duration of the bioanalytical measurements. Measurements were conducted to study the simultaneous changes in oxygen and nitric oxide levels in cultured fibroblast cells in the presence of growth hormones that cause cell proliferation. Increases in oxygen consumption of the cells were coupled with increases in nitric oxide levels when in the presence of the growth hormones. Use of a biological detergent to cause an oxidative burst resulted in a large increase in the current for potentials set to detect nitric oxide and oxygen

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Published date: January 2008
Keywords: microelectrode array, nitric oxide, oxygen, fibroblast cell, film coating


Local EPrints ID: 155785
ISSN: 1618-2642
PURE UUID: df26bc9b-d825-401d-99ea-e0bb4b9082d7

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Date deposited: 28 May 2010 13:36
Last modified: 18 Jul 2017 12:44

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Author: Bhavik Anil Patel
Author: Martin Arundell
Author: Ruben G.W. Quek
Author: Severin L.R. Harvey
Author: Ian R. Ellis
Author: Margaret M. Florence
Author: Anthony E.G. Cass
Author: Ana M. Schor
Author: Danny O'Hare

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