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Bacterial biofilms: from the natural environment to infectious diseases

Hall-Stoodley, Luanne, Costerton, J. William and Stoodley, Paul (2004) Bacterial biofilms: from the natural environment to infectious diseases Nature Reviews Microbiology, 2, (2), pp. 95-108. (doi:10.1038/nrmicro821).

Record type: Article


Biofilms — matrix-enclosed microbial accretions that adhere to biological or non-biological surfaces — represent a significant and incompletely understood mode of growth for bacteria. Biofilm formation appears early in the fossil record (3.25 billion years ago) and is common throughout a diverse range of organisms in both the Archaea and Bacteria lineages, including the 'living fossils' in the most deeply dividing branches of the phylogenetic tree. It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments. Recent advances show that biofilms are structurally complex, dynamic systems with attributes of both primordial multicellular organisms and multifaceted ecosystems. Biofilm formation represents a protected mode of growth that allows cells to survive in hostile environments and also disperse to colonize new niches. The implications of these survival and propagative mechanisms in the context of both the natural environment and infectious diseases are discussed in this review.

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Published date: February 2004
Organisations: Engineering Mats & Surface Engineerg Gp


Local EPrints ID: 155911
ISSN: 1740-1526
PURE UUID: 95550162-9873-4b74-b1eb-e3d7c528ee4a

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Date deposited: 09 Jun 2010 10:50
Last modified: 18 Jul 2017 12:43

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Author: Luanne Hall-Stoodley
Author: J. William Costerton
Author: Paul Stoodley

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