Viscoelasticity of staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration
Viscoelasticity of staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration
Staphylococcus aureus is a leading cause of catheter-related bloodstream infections and endocarditis. Both involve (i) biofilm formation, (ii) exposure to fluid shear, and (iii) high rates of dissemination. We found that viscoelasticity allowed S. aureus biofilms to resist detachment due to increased fluid shear by deformation, while remaining attached to a surface. Further, we report that S. aureus microcolonies moved downstream by rolling along the lumen walls of a glass flow cell, driven by the flow of the overlying fluid. The rolling appeared to be controlled by viscoelastic tethers. This tethered rolling may be important for the surface colonization of medical devices by nonmotile bacteria.
2175-2178
Rupp, Cory J.
530ea5ae-8b9f-4190-80cb-777306d60d4f
Fux, Christoph A.
14e6c1bf-9519-4dbf-940a-7a15fc2ae563
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
April 2005
Rupp, Cory J.
530ea5ae-8b9f-4190-80cb-777306d60d4f
Fux, Christoph A.
14e6c1bf-9519-4dbf-940a-7a15fc2ae563
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Rupp, Cory J., Fux, Christoph A. and Stoodley, Paul
(2005)
Viscoelasticity of staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration.
Applied and Environmental Microbiology, 71 (4), .
Abstract
Staphylococcus aureus is a leading cause of catheter-related bloodstream infections and endocarditis. Both involve (i) biofilm formation, (ii) exposure to fluid shear, and (iii) high rates of dissemination. We found that viscoelasticity allowed S. aureus biofilms to resist detachment due to increased fluid shear by deformation, while remaining attached to a surface. Further, we report that S. aureus microcolonies moved downstream by rolling along the lumen walls of a glass flow cell, driven by the flow of the overlying fluid. The rolling appeared to be controlled by viscoelastic tethers. This tethered rolling may be important for the surface colonization of medical devices by nonmotile bacteria.
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Published date: April 2005
Organisations:
Engineering Mats & Surface Engineerg Gp
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Local EPrints ID: 155973
URI: http://eprints.soton.ac.uk/id/eprint/155973
ISSN: 0099-2240
PURE UUID: b0c8392a-2b84-45dc-bd44-3e331730d5c5
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Date deposited: 08 Jun 2010 16:07
Last modified: 08 Jan 2022 03:10
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Author:
Cory J. Rupp
Author:
Christoph A. Fux
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