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Viscoelasticity of staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration

Rupp, Cory J., Fux, Christoph A. and Stoodley, Paul (2005) Viscoelasticity of staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration Applied and Environmental Microbiology, 71, (4), pp. 2175-2178.

Record type: Article

Abstract

Staphylococcus aureus is a leading cause of catheter-related bloodstream infections and endocarditis. Both involve (i) biofilm formation, (ii) exposure to fluid shear, and (iii) high rates of dissemination. We found that viscoelasticity allowed S. aureus biofilms to resist detachment due to increased fluid shear by deformation, while remaining attached to a surface. Further, we report that S. aureus microcolonies moved downstream by rolling along the lumen walls of a glass flow cell, driven by the flow of the overlying fluid. The rolling appeared to be controlled by viscoelastic tethers. This tethered rolling may be important for the surface colonization of medical devices by nonmotile bacteria.

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More information

Published date: April 2005
Organisations: Engineering Mats & Surface Engineerg Gp

Identifiers

Local EPrints ID: 155973
URI: http://eprints.soton.ac.uk/id/eprint/155973
ISSN: 0099-2240
PURE UUID: b0c8392a-2b84-45dc-bd44-3e331730d5c5

Catalogue record

Date deposited: 08 Jun 2010 16:07
Last modified: 18 Jul 2017 12:43

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Contributors

Author: Cory J. Rupp
Author: Christoph A. Fux
Author: Paul Stoodley

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