The University of Southampton
University of Southampton Institutional Repository

Can laboratory reference strains mirror "real-world" pathogenesis?

Record type: Article

The extraordinary plasticity of bacterial genomes raises concerns about the adequacy of laboratory-adapted reference strains for the study of "real-world" pathogenesis. Some laboratory strains have been sub-cultured for decades since their first isolation and might have lost important pathophysiological characteristics. Evidence is presented that bacteria rapidly adapt to in vitro conditions. Genomic differences between laboratory reference strains and corresponding low-passage clinical isolates are reviewed. It appears that no bacterial strain can truly represent its species. For DNA microarray and proteomic studies, this limitation might be overcome by the summation of individual genomes to produce a species-specific virtual supragenome.

Full text not available from this repository.

Citation

Fux, C.A., Shirtliff, M., Stoodley, P. and Costerton, J.W. (2005) Can laboratory reference strains mirror "real-world" pathogenesis? Trends in Microbiology, 13, (2), pp. 58-63. (doi:10.1016/j.tim.2004.11.001).

More information

Published date: February 2005
Organisations: Engineering Mats & Surface Engineerg Gp

Identifiers

Local EPrints ID: 155975
URI: http://eprints.soton.ac.uk/id/eprint/155975
ISSN: 0966-842X
PURE UUID: cac855d5-20e1-475f-897b-377a7a038ae5

Catalogue record

Date deposited: 08 Jun 2010 16:13
Last modified: 18 Jul 2017 12:43

Export record

Altmetrics

Contributors

Author: C.A. Fux
Author: M. Shirtliff
Author: P. Stoodley
Author: J.W. Costerton

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×