Can laboratory reference strains mirror "real-world" pathogenesis?

Fux, C.A., Shirtliff, M., Stoodley, P. and Costerton, J.W. (2005) Can laboratory reference strains mirror "real-world" pathogenesis? Trends in Microbiology, 13, (2), pp. 58-63. (doi:10.1016/j.tim.2004.11.001).


Full text not available from this repository.


The extraordinary plasticity of bacterial genomes raises concerns about the adequacy of laboratory-adapted reference strains for the study of "real-world" pathogenesis. Some laboratory strains have been sub-cultured for decades since their first isolation and might have lost important pathophysiological characteristics. Evidence is presented that bacteria rapidly adapt to in vitro conditions. Genomic differences between laboratory reference strains and corresponding low-passage clinical isolates are reviewed. It appears that no bacterial strain can truly represent its species. For DNA microarray and proteomic studies, this limitation might be overcome by the summation of individual genomes to produce a species-specific virtual supragenome.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.tim.2004.11.001
ISSNs: 0966-842X (print)
Related URLs:
Organisations: Engineering Mats & Surface Engineerg Gp
ePrint ID: 155975
Date :
Date Event
February 2005Published
Date Deposited: 08 Jun 2010 16:13
Last Modified: 18 Apr 2017 04:02
Further Information:Google Scholar

Actions (login required)

View Item View Item