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Can laboratory reference strains mirror "real-world" pathogenesis?

Fux, C.A., Shirtliff, M., Stoodley, P. and Costerton, J.W. (2005) Can laboratory reference strains mirror "real-world" pathogenesis? Trends in Microbiology, 13, (2), pp. 58-63. (doi:10.1016/j.tim.2004.11.001).

Record type: Article


The extraordinary plasticity of bacterial genomes raises concerns about the adequacy of laboratory-adapted reference strains for the study of "real-world" pathogenesis. Some laboratory strains have been sub-cultured for decades since their first isolation and might have lost important pathophysiological characteristics. Evidence is presented that bacteria rapidly adapt to in vitro conditions. Genomic differences between laboratory reference strains and corresponding low-passage clinical isolates are reviewed. It appears that no bacterial strain can truly represent its species. For DNA microarray and proteomic studies, this limitation might be overcome by the summation of individual genomes to produce a species-specific virtual supragenome.

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Published date: February 2005
Organisations: Engineering Mats & Surface Engineerg Gp


Local EPrints ID: 155975
ISSN: 0966-842X
PURE UUID: cac855d5-20e1-475f-897b-377a7a038ae5

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Date deposited: 08 Jun 2010 16:13
Last modified: 18 Jul 2017 12:43

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Author: C.A. Fux
Author: M. Shirtliff
Author: P. Stoodley
Author: J.W. Costerton

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