On a biophysical and mathematical model of pgp-mediated multidrug resistance: understanding the “space–time” dimension of MDR
On a biophysical and mathematical model of pgp-mediated multidrug resistance: understanding the “space–time” dimension of MDR
Multidrug resistance (MDR) is explained by drug transporters with a drug-handling activity. Despite much work, MDR remains multifaceted, and several conditions are required to generate drug resistance. The drug pumping was conceptually described using a kinetic, i.e., temporal, approach. The re-emergence of physical biology has allowed us to take into account new parameters focusing on the notion of space. This, in turn, has given us important clues regarding the process whereby drug and transporter interact. We will demonstrate that the likelihood of drug-transporter meeting (i.e., the affinity) and thus interaction are also driven by the mechanical interaction between drug molecular weight (MW) and the membrane mechanical properties. This should allow us to mechanically control drug delivery.
physical biology, pharmacokinetic, membrane, drug delivery, multi-drug resistance, lipinski’s second rule
201-211
Panagiotopoulou, Vasiliki
6389b6ee-9e14-49a2-b1fb-3487bf62c894
Richardson, Giles
3fd8e08f-e615-42bb-a1ff-3346c5847b91
Jensen, Oliver E.
efc79b33-9dce-4600-8a10-33692c1fbbda
Rauch, Cyril
e17da1e8-0c88-4bac-ad20-c9b61de88e2d
January 2010
Panagiotopoulou, Vasiliki
6389b6ee-9e14-49a2-b1fb-3487bf62c894
Richardson, Giles
3fd8e08f-e615-42bb-a1ff-3346c5847b91
Jensen, Oliver E.
efc79b33-9dce-4600-8a10-33692c1fbbda
Rauch, Cyril
e17da1e8-0c88-4bac-ad20-c9b61de88e2d
Panagiotopoulou, Vasiliki, Richardson, Giles, Jensen, Oliver E. and Rauch, Cyril
(2010)
On a biophysical and mathematical model of pgp-mediated multidrug resistance: understanding the “space–time” dimension of MDR.
European Biophysics Journal, 39 (2), .
(doi:10.1007/s00249-009-0555-5).
Abstract
Multidrug resistance (MDR) is explained by drug transporters with a drug-handling activity. Despite much work, MDR remains multifaceted, and several conditions are required to generate drug resistance. The drug pumping was conceptually described using a kinetic, i.e., temporal, approach. The re-emergence of physical biology has allowed us to take into account new parameters focusing on the notion of space. This, in turn, has given us important clues regarding the process whereby drug and transporter interact. We will demonstrate that the likelihood of drug-transporter meeting (i.e., the affinity) and thus interaction are also driven by the mechanical interaction between drug molecular weight (MW) and the membrane mechanical properties. This should allow us to mechanically control drug delivery.
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Published date: January 2010
Keywords:
physical biology, pharmacokinetic, membrane, drug delivery, multi-drug resistance, lipinski’s second rule
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Local EPrints ID: 156333
URI: http://eprints.soton.ac.uk/id/eprint/156333
ISSN: 0175-7571
PURE UUID: 2bb33257-8681-4269-bcbd-3a24177781ec
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Date deposited: 02 Jun 2010 09:54
Last modified: 14 Mar 2024 02:54
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Contributors
Author:
Vasiliki Panagiotopoulou
Author:
Oliver E. Jensen
Author:
Cyril Rauch
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