Toward a mathematical model of assembly and disassembly of membrane microdomains: comparison with experimental models
Toward a mathematical model of assembly and disassembly of membrane microdomains: comparison with experimental models
We study a model system in which lipid bilayers are created using variable (precisely known) proportions of phosphatidylcholine and cholesterol. The model membranes exhibit cholesterol-enriched microdomains that are analogous to the so-called “lipid rafts” that form in living cells. After briefly presenting some experimental results, we formulate and solve a novel mathematical model based on the Smoluchowski equations for coagulation and fragmentation. We present a comparison between the distribution of lipid-raft areas observed in experimental lipid bilayers, and that distribution predicted by the theoretical model. Excellent agreement between the experiments and theory is obtained, with minimal parameter fitting.
4145-4156
Richardson, Giles
3fd8e08f-e615-42bb-a1ff-3346c5847b91
Cummings, Linda Jane
8a6d52ea-afc2-4617-afe2-9388662c74a9
Harris, H.J.
63bc3e0d-791d-4c1b-af9b-e93d0417e82f
O'Shea, Paul
50c6f5af-a0e0-478a-8c3d-25851ed171dc
15 June 2007
Richardson, Giles
3fd8e08f-e615-42bb-a1ff-3346c5847b91
Cummings, Linda Jane
8a6d52ea-afc2-4617-afe2-9388662c74a9
Harris, H.J.
63bc3e0d-791d-4c1b-af9b-e93d0417e82f
O'Shea, Paul
50c6f5af-a0e0-478a-8c3d-25851ed171dc
Richardson, Giles, Cummings, Linda Jane, Harris, H.J. and O'Shea, Paul
(2007)
Toward a mathematical model of assembly and disassembly of membrane microdomains: comparison with experimental models.
Biophysical Journal, 92 (12), .
(doi:10.1529/biophysj.106.090233).
Abstract
We study a model system in which lipid bilayers are created using variable (precisely known) proportions of phosphatidylcholine and cholesterol. The model membranes exhibit cholesterol-enriched microdomains that are analogous to the so-called “lipid rafts” that form in living cells. After briefly presenting some experimental results, we formulate and solve a novel mathematical model based on the Smoluchowski equations for coagulation and fragmentation. We present a comparison between the distribution of lipid-raft areas observed in experimental lipid bilayers, and that distribution predicted by the theoretical model. Excellent agreement between the experiments and theory is obtained, with minimal parameter fitting.
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Accepted/In Press date: 14 December 2006
Published date: 15 June 2007
Identifiers
Local EPrints ID: 156351
URI: http://eprints.soton.ac.uk/id/eprint/156351
ISSN: 0006-3495
PURE UUID: dcec3daa-d124-4e45-9b86-3c302cd34b83
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Date deposited: 03 Jun 2010 09:20
Last modified: 14 Mar 2024 02:54
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Author:
Linda Jane Cummings
Author:
H.J. Harris
Author:
Paul O'Shea
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