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Catalytic and non-catalytic functions of human IIA phospholipase A2

Birts, Charles N., Barton, C. Howard and Wilton, David C. (2010) Catalytic and non-catalytic functions of human IIA phospholipase A2 Trends in Biochemical Sciences, 35, (1), pp. 28-35. (doi:10.1016/j.tibs.2009.08.003).

Record type: Article


Group IIA phospholipase A2 (PLA2) is a low-molecular-mass secreted PLA2 enzyme that has been identified as an acute phase protein with a role in the inflammatory response to infection and trauma. The protein is possibly unique in being highly cationic and having a global distribution of surface arginine and lysine residues. This structure supports two functions of the protein. (1) An anti-bacterial role where the enzyme is targeted to the anionic cell membrane of Gram-positive bacteria and phospholipid hydrolysis assists in bacterial killing. (2) A proposed non-catalytic role in which the protein forms supramolecular aggregates with anionic phospholipid vesicles or debris. These aggregates are then internalized via interactions with cell surface heparin sulphate proteoglycans and macropinocytosis for disposal by macrophages. Copyright 2009 Elsevier Ltd. All rights reserved.

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Published date: 2010


Local EPrints ID: 156557
PURE UUID: 4fc267d4-e4e5-47ec-bdb4-61ea3d482474
ORCID for Charles N. Birts: ORCID iD

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Date deposited: 01 Jun 2010 10:44
Last modified: 18 Jul 2017 12:42

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