Inflammation in aging part 2: implications for the health of older people and recommendations for nursing practice
Inflammation in aging part 2: implications for the health of older people and recommendations for nursing practice
Aging is accompanied by declining function and remodeling of body systems. In particular, changes to the immune and endocrine systems have far-reaching effects that cause an increase in cytokine release and decrease in anti-inflammatory feedback systems. The chronic inflammation that ensues has been named ‘‘inflammaging.’’ Inflammaging is associated with many detrimental effects that combine to increase morbidity and mortality. The sickness behavior that arises from inflammatory processes and the side effects of chronic diseases lead to a constellation of symptoms that decrease quality of life and affect the well-being of the individual. Part 2 of this two-part article provides an overview of the health effects of inflammaging, addressing the extent to which it contributes to the syndromes of frailty and disability with aging.
inflammaging, IL-6 • TNF-, anemia, osteopenia, sarcopenia, frailty
253-260
Hunt, Katherine J.
5eab8123-1157-4d4e-a7d9-5fd817218c6e
Walsh, Bronagh
5818243e-048d-4b4b-88c5-231b0e419427
Voegeli, David
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Roberts, Helen C.
5ea688b1-ef7a-4173-9da0-26290e18f253
2010
Hunt, Katherine J.
5eab8123-1157-4d4e-a7d9-5fd817218c6e
Walsh, Bronagh
5818243e-048d-4b4b-88c5-231b0e419427
Voegeli, David
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Roberts, Helen C.
5ea688b1-ef7a-4173-9da0-26290e18f253
Hunt, Katherine J., Walsh, Bronagh, Voegeli, David and Roberts, Helen C.
(2010)
Inflammation in aging part 2: implications for the health of older people and recommendations for nursing practice.
Biological Research for Nursing, 11 (3), .
(doi:10.1177/1099800409352377).
Abstract
Aging is accompanied by declining function and remodeling of body systems. In particular, changes to the immune and endocrine systems have far-reaching effects that cause an increase in cytokine release and decrease in anti-inflammatory feedback systems. The chronic inflammation that ensues has been named ‘‘inflammaging.’’ Inflammaging is associated with many detrimental effects that combine to increase morbidity and mortality. The sickness behavior that arises from inflammatory processes and the side effects of chronic diseases lead to a constellation of symptoms that decrease quality of life and affect the well-being of the individual. Part 2 of this two-part article provides an overview of the health effects of inflammaging, addressing the extent to which it contributes to the syndromes of frailty and disability with aging.
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Published date: 2010
Keywords:
inflammaging, IL-6 • TNF-, anemia, osteopenia, sarcopenia, frailty
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Local EPrints ID: 156597
URI: http://eprints.soton.ac.uk/id/eprint/156597
ISSN: 1099-8004
PURE UUID: fcfa830f-bd92-4514-a529-15771cd69771
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Date deposited: 01 Jun 2010 11:56
Last modified: 25 Jun 2024 01:43
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Author:
David Voegeli
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