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Genetic loci influencing kidney function and chronic kidney disease

Genetic loci influencing kidney function and chronic kidney disease
Genetic loci influencing kidney function and chronic kidney disease
Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10?10 to 10?15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10?5 and P = 3.6 × 10?4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease
1061-4036
373-375
Chambers, John C
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Zhang, Weihua
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Lord, Graham M
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van der Harst, Pim
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Lawlor, Debbie A
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Sehmi, Joban S
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Gale, Daniel P
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Wass, Mark N
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Ahmadi, Kourosh R
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Bakker, Stephan J L
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Beckmann, Jacqui
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Bilo, Henk J G
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Bochud, Murielle
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Brown, Morris J
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Caulfield, Mark J
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Connell, John M C
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Cook, H Terence
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Cotlarciuc, Ioana
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Smith, George Davey
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de Silva, Ranil
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Deng, Guohong
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Devuyst, Olivier
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Roderick, Paul
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Dikkeschei, Lambert D
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Dimkovic, Nada
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Dockrell, Mark
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Chambers, John C
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Zhang, Weihua
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Lord, Graham M
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van der Harst, Pim
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Lawlor, Debbie A
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Sehmi, Joban S
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Gale, Daniel P
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Wass, Mark N
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Ahmadi, Kourosh R
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Bakker, Stephan J L
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Beckmann, Jacqui
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Bilo, Henk J G
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Bochud, Murielle
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Brown, Morris J
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Caulfield, Mark J
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Connell, John M C
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Cook, H Terence
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Cotlarciuc, Ioana
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Smith, George Davey
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de Silva, Ranil
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Deng, Guohong
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Devuyst, Olivier
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Roderick, Paul
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Dikkeschei, Lambert D
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Dimkovic, Nada
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Dockrell, Mark
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Chambers, John C, Zhang, Weihua, Lord, Graham M, van der Harst, Pim, Lawlor, Debbie A, Sehmi, Joban S, Gale, Daniel P, Wass, Mark N, Ahmadi, Kourosh R, Bakker, Stephan J L, Beckmann, Jacqui, Bilo, Henk J G, Bochud, Murielle, Brown, Morris J, Caulfield, Mark J, Connell, John M C, Cook, H Terence, Cotlarciuc, Ioana, Smith, George Davey, de Silva, Ranil, Deng, Guohong, Devuyst, Olivier, Roderick, Paul, Dikkeschei, Lambert D, Dimkovic, Nada and Dockrell, Mark (2010) Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42 (5), 373-375. (doi:10.1038/ng.566).

Record type: Article

Abstract

Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10?10 to 10?15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10?5 and P = 3.6 × 10?4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease

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Published date: May 2010
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 156689
URI: https://eprints.soton.ac.uk/id/eprint/156689
ISSN: 1061-4036
PURE UUID: d6e78f9f-d8d0-4ebb-9479-56eb5055b876
ORCID for Paul Roderick: ORCID iD orcid.org/0000-0001-9475-6850

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Date deposited: 02 Jun 2010 13:37
Last modified: 19 Jul 2019 01:14

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Contributors

Author: John C Chambers
Author: Weihua Zhang
Author: Graham M Lord
Author: Pim van der Harst
Author: Debbie A Lawlor
Author: Joban S Sehmi
Author: Daniel P Gale
Author: Mark N Wass
Author: Kourosh R Ahmadi
Author: Stephan J L Bakker
Author: Jacqui Beckmann
Author: Henk J G Bilo
Author: Murielle Bochud
Author: Morris J Brown
Author: Mark J Caulfield
Author: John M C Connell
Author: H Terence Cook
Author: Ioana Cotlarciuc
Author: George Davey Smith
Author: Ranil de Silva
Author: Guohong Deng
Author: Olivier Devuyst
Author: Paul Roderick ORCID iD
Author: Lambert D Dikkeschei
Author: Nada Dimkovic
Author: Mark Dockrell

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