Remote memory deficits in transient epileptic amnesia
Remote memory deficits in transient epileptic amnesia
Transient epileptic amnesia is a form of temporal lobe epilepsy in which sufferers often complain of irretrievable loss of remote memories. We used a broad range of memory tests to clarify the extent and nature of the remote memory deficits in patients with transient epileptic amnesia. Performance on standard tests of anterograde memory was normal. In contrast, there was a severe impairment of memory for autobiographical events extending across the entire lifespan, providing evidence for the occurrence of ‘focal retrograde amnesia’ in transient epileptic amnesia. There was a milder impairment of personal semantic memory, most pronounced for midlife years. There were limited deficits of public semantic memory for recent decades. These results may reflect subtle structural pathology in the medial temporal lobes or the effects of the propagation of epileptiform activity through the network of brain regions responsible for long-term memory, or a combination of these two mechanisms.
1368-1379
Milton, Fraser
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Muhlert, Nils
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Pindus, Dominika M.
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Butler, Christopher R.
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Kapur, Narinder
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Graham, Kim S.
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Zeman, Adam Z. J.
406d1f14-2715-42e5-8360-c5e30a3f22e7
2010
Milton, Fraser
383d40fb-7a24-4086-b58d-ece5deea0910
Muhlert, Nils
bf1db4e6-36a7-4637-9a68-cd5ef13def40
Pindus, Dominika M.
779f1d6b-8890-4374-bd09-c3dd114c44e1
Butler, Christopher R.
89456e4a-422a-458b-bcea-7bc3300fcd11
Kapur, Narinder
9ea5d758-bba6-4bc9-be6b-b056c0c83d9d
Graham, Kim S.
c0e0b047-099f-45ab-ade4-85f9f184f24b
Zeman, Adam Z. J.
406d1f14-2715-42e5-8360-c5e30a3f22e7
Milton, Fraser, Muhlert, Nils, Pindus, Dominika M., Butler, Christopher R., Kapur, Narinder, Graham, Kim S. and Zeman, Adam Z. J.
(2010)
Remote memory deficits in transient epileptic amnesia.
Brain, 133 (5), .
(doi:10.1093/brain/awq055).
Abstract
Transient epileptic amnesia is a form of temporal lobe epilepsy in which sufferers often complain of irretrievable loss of remote memories. We used a broad range of memory tests to clarify the extent and nature of the remote memory deficits in patients with transient epileptic amnesia. Performance on standard tests of anterograde memory was normal. In contrast, there was a severe impairment of memory for autobiographical events extending across the entire lifespan, providing evidence for the occurrence of ‘focal retrograde amnesia’ in transient epileptic amnesia. There was a milder impairment of personal semantic memory, most pronounced for midlife years. There were limited deficits of public semantic memory for recent decades. These results may reflect subtle structural pathology in the medial temporal lobes or the effects of the propagation of epileptiform activity through the network of brain regions responsible for long-term memory, or a combination of these two mechanisms.
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Published date: 2010
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Local EPrints ID: 156723
URI: http://eprints.soton.ac.uk/id/eprint/156723
ISSN: 0006-8950
PURE UUID: b08bc8ce-1c6c-44bc-91ed-167064301b4b
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Date deposited: 01 Jun 2010 15:56
Last modified: 14 Mar 2024 01:45
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Contributors
Author:
Fraser Milton
Author:
Nils Muhlert
Author:
Dominika M. Pindus
Author:
Christopher R. Butler
Author:
Narinder Kapur
Author:
Kim S. Graham
Author:
Adam Z. J. Zeman
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