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The role of NF-kappaB in lymphoid malignancies

The role of NF-kappaB in lymphoid malignancies
The role of NF-kappaB in lymphoid malignancies
Nuclear Factor kappaB (NF-kappaB) transcription factors are central regulators of lymphocyte proliferation, survival and development. Although normally subject to tight control, constitutive activation of NF-kappaB promotes inappropriate lymphocyte survival and proliferation, and is recognised as key pathological feature in various lymphoid malignancies. Inhibition of NF-kappaB may be an attractive therapeutic approach in these diseases. This review focuses on the mechanisms and functional consequences of NF-kappaB activation in lymphoid malignancies and potential therapeutic strategies for inhibition of NF-kappaB.

NF-?B, lymphoma, leukaemia, apoptosis, inhibitor, proteasome
0007-1048
3-15
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394

Packham, Graham (2008) The role of NF-kappaB in lymphoid malignancies. British Journal of Haematology, 143 (1), 3-15. (doi:10.1111/j.1365-2141.2008.07284.x).

Record type: Article

Abstract

Nuclear Factor kappaB (NF-kappaB) transcription factors are central regulators of lymphocyte proliferation, survival and development. Although normally subject to tight control, constitutive activation of NF-kappaB promotes inappropriate lymphocyte survival and proliferation, and is recognised as key pathological feature in various lymphoid malignancies. Inhibition of NF-kappaB may be an attractive therapeutic approach in these diseases. This review focuses on the mechanisms and functional consequences of NF-kappaB activation in lymphoid malignancies and potential therapeutic strategies for inhibition of NF-kappaB.

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Published date: September 2008
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Keywords: NF-?B, lymphoma, leukaemia, apoptosis, inhibitor, proteasome

Identifiers

Local EPrints ID: 157107
URI: http://eprints.soton.ac.uk/id/eprint/157107
DOI: doi:10.1111/j.1365-2141.2008.07284.x
ISSN: 0007-1048
PURE UUID: f8269950-bfa1-48bd-97c5-dcad919ffe33
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691

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Date deposited: 03 Jun 2010 15:53
Last modified: 14 Mar 2024 02:44

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Author: Graham Packham ORCID iD

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