Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms
Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms
Staphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.
6339-6345
Leid, Jeff G.
7b095972-1283-4371-b8a6-8cbf667d6b33
Shirtliff, Mark E.
38eb9180-8d02-4f86-bbdb-3f58734604e5
Costerton, J. W.
228b5d89-a8a6-4832-a265-29ce63868a87
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
November 2002
Leid, Jeff G.
7b095972-1283-4371-b8a6-8cbf667d6b33
Shirtliff, Mark E.
38eb9180-8d02-4f86-bbdb-3f58734604e5
Costerton, J. W.
228b5d89-a8a6-4832-a265-29ce63868a87
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Leid, Jeff G., Shirtliff, Mark E., Costerton, J. W. and Stoodley, Paul
(2002)
Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms.
Infection and Immunity, 70 (11), .
(doi:10.1128/IAI.70.11.6339-6345.2002).
Abstract
Staphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.
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Published date: November 2002
Organisations:
Engineering Mats & Surface Engineerg Gp
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Local EPrints ID: 157139
URI: http://eprints.soton.ac.uk/id/eprint/157139
ISSN: 0019-9567
PURE UUID: 0300ad71-8cb0-4e0d-97de-604a3d0b43b4
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Date deposited: 09 Jun 2010 14:29
Last modified: 14 Mar 2024 02:55
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Author:
Jeff G. Leid
Author:
Mark E. Shirtliff
Author:
J. W. Costerton
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