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Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms

Leid, Jeff G., Shirtliff, Mark E., Costerton, J. W. and Stoodley, Paul (2002) Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms Infection and Immunity, 70, (11), pp. 6339-6345. (doi:10.1128/IAI.70.11.6339-6345.2002).

Record type: Article

Abstract

Staphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.

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Published date: November 2002
Organisations: Engineering Mats & Surface Engineerg Gp

Identifiers

Local EPrints ID: 157139
URI: http://eprints.soton.ac.uk/id/eprint/157139
ISSN: 0019-9567
PURE UUID: 0300ad71-8cb0-4e0d-97de-604a3d0b43b4

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Date deposited: 09 Jun 2010 14:29
Last modified: 18 Jul 2017 12:41

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Contributors

Author: Jeff G. Leid
Author: Mark E. Shirtliff
Author: J. W. Costerton
Author: Paul Stoodley

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