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The histological features of intestinal spirochetosis in a series of 113 patients.

The histological features of intestinal spirochetosis in a series of 113 patients.
The histological features of intestinal spirochetosis in a series of 113 patients.
A multicenter retrospective review of cases diagnosed as spirochetosis was performed to determine the presenting symptoms and histological changes. A total of 113 cases were retrieved from the archives, comprising 97 colorectal specimens and 16 appendices. In only 25 cases was the presenting symptom recorded as diarrhea. Of the colorectal specimens, 87 (90%) showed no mucosal abnormality (apart from the spirochetes); the other 10 showed mucosal inflammation but 6 of them had a diagnosis of another inflammatory disease process accounting for the inflammatory changes. Five appendices showed acute appendicitis; the other 11 were unremarkable. We conclude that spirochetosis in an unselected general population is unlikely to be of pathological significance. Furthermore, if spirochetosis is observed in an inflamed biopsy, it is most likely to be an incidental finding.
diarrhea, spirochetosis, intestinal, Brachyspira, human
1066-8969
144-148
Carr, Norman J.
810e44dc-90d5-496c-85b6-6b2fa1c07dd7
Mahajan, Hema.
3cfd1e53-48ce-4d5a-b5ee-6c814d89bc6f
Tan, King L.
3bea66ff-e710-42dc-9ded-112b5f5c6f28
Sharma, Raghwa.
65a5da6e-d522-41dc-bc9e-fdbc679c2172
Carr, Norman J.
810e44dc-90d5-496c-85b6-6b2fa1c07dd7
Mahajan, Hema.
3cfd1e53-48ce-4d5a-b5ee-6c814d89bc6f
Tan, King L.
3bea66ff-e710-42dc-9ded-112b5f5c6f28
Sharma, Raghwa.
65a5da6e-d522-41dc-bc9e-fdbc679c2172

Carr, Norman J., Mahajan, Hema., Tan, King L. and Sharma, Raghwa. (2010) The histological features of intestinal spirochetosis in a series of 113 patients. International Journal of Surgical Pathology, 18 (2), 144-148. (doi:10.1177/1066896908330203). (PMID:19117973)

Record type: Article

Abstract

A multicenter retrospective review of cases diagnosed as spirochetosis was performed to determine the presenting symptoms and histological changes. A total of 113 cases were retrieved from the archives, comprising 97 colorectal specimens and 16 appendices. In only 25 cases was the presenting symptom recorded as diarrhea. Of the colorectal specimens, 87 (90%) showed no mucosal abnormality (apart from the spirochetes); the other 10 showed mucosal inflammation but 6 of them had a diagnosis of another inflammatory disease process accounting for the inflammatory changes. Five appendices showed acute appendicitis; the other 11 were unremarkable. We conclude that spirochetosis in an unselected general population is unlikely to be of pathological significance. Furthermore, if spirochetosis is observed in an inflamed biopsy, it is most likely to be an incidental finding.

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Published date: 1 April 2010
Keywords: diarrhea, spirochetosis, intestinal, Brachyspira, human

Identifiers

Local EPrints ID: 157553
URI: https://eprints.soton.ac.uk/id/eprint/157553
ISSN: 1066-8969
PURE UUID: 529bae6a-33bb-42d8-8c4c-86403ad89273

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Date deposited: 10 Jun 2010 13:31
Last modified: 16 Jul 2019 23:56

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Contributors

Author: Norman J. Carr
Author: Hema. Mahajan
Author: King L. Tan
Author: Raghwa. Sharma

University divisions

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