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Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy

Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy
Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy
Antineural antibody activity is the implicated pathogenic mechanism in polyneuropathy associated with monoclonal gammopathy. Recognition of antigen depends on immunoglobulin variable regions, encoded by V genes. We studied V(H)DJ(H) and V(L)J(L) gene use in monoclonal B cells by clonal analysis in 20 patients with polyneuropathy and IgM monoclonal gammopathy. V genes associated with bacterial responses appear over-represented and V(H)3-23 was preferentially used, without association with specific D, J(H) or V(L)J(L). V genes revealed somatic mutation and intraclonal variation was found in 9 of 20 patients. Polyneuropathy associated with monoclonal gammopathy may be caused by an immune response to bacterial antigens, which recruit somatically mutated autoreactive B cells.
polyneuropathy, monoclonal gammopathy, v gene analysis, anti-mag, antiganglioside
0165-5728
152-159
Eurelings, Marijke
f5e5e51a-19af-43f9-86ef-a38e82a714b2
Notermans, Nicolette C.
6048791e-f35c-4204-97ca-7b097e54762b
Lokhorst, Henk M.
b34bd3e6-c182-4202-9d9b-3dba4024b3ae
van Kessel, Berris
70819739-d4dd-4ae0-9a46-7f4ee00d12bb
Jacobs, Bart C.
2851a019-f6f5-4e5d-a828-a123e14d365b
Wokke, John H.J.
454bafc1-3245-4c5d-a365-dd3bfb0e8425
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Bloem, Andries C.
23947fda-dbec-4633-bcd4-5ebd8beee251
Eurelings, Marijke
f5e5e51a-19af-43f9-86ef-a38e82a714b2
Notermans, Nicolette C.
6048791e-f35c-4204-97ca-7b097e54762b
Lokhorst, Henk M.
b34bd3e6-c182-4202-9d9b-3dba4024b3ae
van Kessel, Berris
70819739-d4dd-4ae0-9a46-7f4ee00d12bb
Jacobs, Bart C.
2851a019-f6f5-4e5d-a828-a123e14d365b
Wokke, John H.J.
454bafc1-3245-4c5d-a365-dd3bfb0e8425
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Bloem, Andries C.
23947fda-dbec-4633-bcd4-5ebd8beee251

Eurelings, Marijke, Notermans, Nicolette C., Lokhorst, Henk M., van Kessel, Berris, Jacobs, Bart C., Wokke, John H.J., Sahota, Surinder S. and Bloem, Andries C. (2006) Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy. Journal of Neuroimmunology, 175 (1-2), 152-159. (doi:10.1016/j.jneuroim.2006.02.008).

Record type: Article

Abstract

Antineural antibody activity is the implicated pathogenic mechanism in polyneuropathy associated with monoclonal gammopathy. Recognition of antigen depends on immunoglobulin variable regions, encoded by V genes. We studied V(H)DJ(H) and V(L)J(L) gene use in monoclonal B cells by clonal analysis in 20 patients with polyneuropathy and IgM monoclonal gammopathy. V genes associated with bacterial responses appear over-represented and V(H)3-23 was preferentially used, without association with specific D, J(H) or V(L)J(L). V genes revealed somatic mutation and intraclonal variation was found in 9 of 20 patients. Polyneuropathy associated with monoclonal gammopathy may be caused by an immune response to bacterial antigens, which recruit somatically mutated autoreactive B cells.

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More information

Published date: June 2006
Keywords: polyneuropathy, monoclonal gammopathy, v gene analysis, anti-mag, antiganglioside

Identifiers

Local EPrints ID: 157793
URI: http://eprints.soton.ac.uk/id/eprint/157793
ISSN: 0165-5728
PURE UUID: f795732c-cc10-41da-bb28-cc637f92cc6f

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Date deposited: 17 Jun 2010 14:01
Last modified: 16 Jul 2019 23:55

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Contributors

Author: Marijke Eurelings
Author: Nicolette C. Notermans
Author: Henk M. Lokhorst
Author: Berris van Kessel
Author: Bart C. Jacobs
Author: John H.J. Wokke
Author: Andries C. Bloem

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