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The genetics of neonatal respiratory disease

The genetics of neonatal respiratory disease
The genetics of neonatal respiratory disease
This chapter reviews some of the genetic predispositions that may govern the presence or severity of neonatal respiratory disorders. Respiratory disease is common in the neonatal period, and genetic factors have been implicated in some rare and common respiratory diseases. Among the most common respiratory diseases are respiratory distress syndrome of the newborn and transient tachypnoea of the newborn, whereas less common ones are cystic fibrosis, congenital alveolar proteinosis and primary ciliary dyskinesias. A common complication of neonatal respiratory distress syndrome is bronchopulmonary dysplasia or neonatal chronic lung disease. This review examines the evidence linking known genetic contributions to these diseases. The value and success of neonatal screening for cystic fibrosis is reviewed, and the recently characterised contribution of polymorphisms and mutations in the surfactant protein genes to neonatal respiratory disease is evaluated. The evidence that known variability in the expression of surfactant protein genes may contribute to the risk of development of neonatal chronic lung disease or bronchopulmonary dysplasia is examined.
271-282
Clark, Howard
a5fd860a-269b-4e37-9075-73f94eb00471
Clark, Lucy Side
44b772d4-456f-46e3-a1d0-810ff8af62fb
Clark, Howard
a5fd860a-269b-4e37-9075-73f94eb00471
Clark, Lucy Side
44b772d4-456f-46e3-a1d0-810ff8af62fb

Clark, Howard and Clark, Lucy Side (2005) The genetics of neonatal respiratory disease. Seminars in Fetal and Neonatal Medicine, 10 (3), 271-282. (doi:10.1016/j.siny.2005.02.004).

Record type: Article

Abstract

This chapter reviews some of the genetic predispositions that may govern the presence or severity of neonatal respiratory disorders. Respiratory disease is common in the neonatal period, and genetic factors have been implicated in some rare and common respiratory diseases. Among the most common respiratory diseases are respiratory distress syndrome of the newborn and transient tachypnoea of the newborn, whereas less common ones are cystic fibrosis, congenital alveolar proteinosis and primary ciliary dyskinesias. A common complication of neonatal respiratory distress syndrome is bronchopulmonary dysplasia or neonatal chronic lung disease. This review examines the evidence linking known genetic contributions to these diseases. The value and success of neonatal screening for cystic fibrosis is reviewed, and the recently characterised contribution of polymorphisms and mutations in the surfactant protein genes to neonatal respiratory disease is evaluated. The evidence that known variability in the expression of surfactant protein genes may contribute to the risk of development of neonatal chronic lung disease or bronchopulmonary dysplasia is examined.

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Published date: June 2005

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Local EPrints ID: 158231
URI: http://eprints.soton.ac.uk/id/eprint/158231
PURE UUID: 2a3617e3-ddcf-44b6-b4e9-c5010627c2ff

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Date deposited: 16 Jun 2010 15:47
Last modified: 05 Oct 2018 12:12

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