The University of Southampton
University of Southampton Institutional Repository

Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D

Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D
Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D
Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactant protein D are biologically active in vivo. This review addresses the structural requirements for recognised activities of SP-D in vitro and in vivo, with emphasis on evidence arising from studies with transgenic mice and mouse models of inflammatory lung disease. The potential of truncated recombinant forms of surfactant protein D as novel therapy for infectious and inflammatory disease is discussed.
0171-2985
619-31
Clark, Howard
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Reid, Kenneth B.M.
74c6c3e3-d682-446d-b159-b635e6056e4e
Clark, Howard
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Reid, Kenneth B.M.
74c6c3e3-d682-446d-b159-b635e6056e4e

Clark, Howard and Reid, Kenneth B.M. (2002) Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D. Immunobiology, 205 (4-5), 619-31. (doi:10.1078/0171-2985-00159).

Record type: Article

Abstract

Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactant protein D are biologically active in vivo. This review addresses the structural requirements for recognised activities of SP-D in vitro and in vivo, with emphasis on evidence arising from studies with transgenic mice and mouse models of inflammatory lung disease. The potential of truncated recombinant forms of surfactant protein D as novel therapy for infectious and inflammatory disease is discussed.

Full text not available from this repository.

More information

Published date: September 2002

Identifiers

Local EPrints ID: 158519
URI: http://eprints.soton.ac.uk/id/eprint/158519
ISSN: 0171-2985
PURE UUID: 9b810f3f-ddc5-409f-bdfd-9f1d64d83dba

Catalogue record

Date deposited: 08 Jul 2010 11:07
Last modified: 16 Jul 2019 23:55

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×