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The ability of peripheral quantitative ultrasound to identify patients with low bone mineral density in the hip or spine

The ability of peripheral quantitative ultrasound to identify patients with low bone mineral density in the hip or spine
The ability of peripheral quantitative ultrasound to identify patients with low bone mineral density in the hip or spine
This study aims to assess the sensitivity and specificity of two commercially available quantitative ultrasound (QUS) scanners (CUBA Clinical™, Sunlight Omnisense™), to differentiate patients with osteoporosis (OP) or osteopenia at the spine and hip confirmed by dual-energy x-ray absorptiometry (DXA) and to investigate the optimum cut-off values to maximize the effectiveness of the screening technique. Participants (n = 268) received DXA scans on their lumbar spine (L1-L4) and hip, with paired QUS scans on their distal radius, proximal phalanx, midshaft tibia and calcaneus. Scanners were evaluated by using receiver-operating characteristics curves and their area under the curve (AUC) values. Measurement of the calcaneus by the CUBA Clinical™ showed a superior ability to predict DXA, with AUC values between 0.75 to 0.83 in comparison with AUC values of 0.60 to 0.70 for the Sunlight Omnisense™. Cut-off values varied according to the technique used and the accuracy of the screening required. Assessment of the calcaneus was the best QUS technique for the prediction of low bone density at the axial skeleton as diagnosed by DXA
osteoporosis, screening, specificity, sensitivity, dxa, ultrasound scanners
0301-5629
625-632
Cook, R.B.
06f8322d-81be-4f82-9326-19e55541c78f
Collins, D.
2b66fd7b-6461-4290-87b0-54fe8fe7e4b6
Tucker, J.
124febb6-dc7f-4dab-b425-ff3e85c81593
Zioupos, P.
11b6158a-2969-43b4-b19b-a01b00ee65fa
Cook, R.B.
06f8322d-81be-4f82-9326-19e55541c78f
Collins, D.
2b66fd7b-6461-4290-87b0-54fe8fe7e4b6
Tucker, J.
124febb6-dc7f-4dab-b425-ff3e85c81593
Zioupos, P.
11b6158a-2969-43b4-b19b-a01b00ee65fa

Cook, R.B., Collins, D., Tucker, J. and Zioupos, P. (2005) The ability of peripheral quantitative ultrasound to identify patients with low bone mineral density in the hip or spine. Ultrasound in Medicine & Biology, 31 (5), 625-632. (doi:10.1016/j.ultrasmedbio.2005.02.003).

Record type: Article

Abstract

This study aims to assess the sensitivity and specificity of two commercially available quantitative ultrasound (QUS) scanners (CUBA Clinical™, Sunlight Omnisense™), to differentiate patients with osteoporosis (OP) or osteopenia at the spine and hip confirmed by dual-energy x-ray absorptiometry (DXA) and to investigate the optimum cut-off values to maximize the effectiveness of the screening technique. Participants (n = 268) received DXA scans on their lumbar spine (L1-L4) and hip, with paired QUS scans on their distal radius, proximal phalanx, midshaft tibia and calcaneus. Scanners were evaluated by using receiver-operating characteristics curves and their area under the curve (AUC) values. Measurement of the calcaneus by the CUBA Clinical™ showed a superior ability to predict DXA, with AUC values between 0.75 to 0.83 in comparison with AUC values of 0.60 to 0.70 for the Sunlight Omnisense™. Cut-off values varied according to the technique used and the accuracy of the screening required. Assessment of the calcaneus was the best QUS technique for the prediction of low bone density at the axial skeleton as diagnosed by DXA

Full text not available from this repository.

More information

Accepted/In Press date: 3 February 2005
e-pub ahead of print date: 28 April 2005
Published date: May 2005
Keywords: osteoporosis, screening, specificity, sensitivity, dxa, ultrasound scanners
Organisations: nCATS Group

Identifiers

Local EPrints ID: 158549
URI: http://eprints.soton.ac.uk/id/eprint/158549
ISSN: 0301-5629
PURE UUID: 969ec291-0854-46c1-ae1c-3123aab98c99

Catalogue record

Date deposited: 20 Jan 2015 11:00
Last modified: 16 Jul 2019 23:55

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