Is lifespan determined in utero?
Is lifespan determined in utero?
Low rates of growth in early life are now known to be associated with an increase in age related disease in later life.1 This is thought to reflect programming, the process whereby a stimulus or insult acting at a critical period of development in early life, has lasting or lifelong importance.2 In animal experiments that have examined the mechanisms responsible for programming, attention has focused on prenatal undernutrition and its influence on gene expression, cell division and differentiation, and tissue structure.
F162-F164
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
November 1997
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Sayer, A.A., Cooper, C. and Barker, D.J.
(1997)
Is lifespan determined in utero?
Archives of Disease in Childhood, 77 (3), .
(doi:10.1136/fn.77.3.F162).
Abstract
Low rates of growth in early life are now known to be associated with an increase in age related disease in later life.1 This is thought to reflect programming, the process whereby a stimulus or insult acting at a critical period of development in early life, has lasting or lifelong importance.2 In animal experiments that have examined the mechanisms responsible for programming, attention has focused on prenatal undernutrition and its influence on gene expression, cell division and differentiation, and tissue structure.
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Published date: November 1997
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Local EPrints ID: 159737
URI: http://eprints.soton.ac.uk/id/eprint/159737
ISSN: 0003-9888
PURE UUID: 662931c2-928c-4e2d-8063-2876b34d63c4
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Date deposited: 07 Jul 2010 14:10
Last modified: 18 Mar 2024 02:45
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Author:
A.A. Sayer
Author:
D.J. Barker
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