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Retinal vascular network architecture in low birth-weight men

Retinal vascular network architecture in low birth-weight men
Retinal vascular network architecture in low birth-weight men
BACKGROUND: Low birth weight is associated with hypertension and increased cardiovascular mortality, but the mechanism of this association is not known. Hypertension is accompanied by abnormalities of the microvasculature including rarefaction. OBJECTIVE: To test the hypothesis that low birth weight is associated with an alteration in microvascular architecture. DESIGN: A stratified random sample of 100 men aged 64-74 years was selected from a cohort of men whose birth weights were known. They were of relatively high or low birth weight ('high' > or = 3700 g, 'low' < or = 3200 g) and high or low systolic blood pressure (high > or = 160 mmHg, low < or = 140 mmHg). METHODS: Retinal arteriolar geometry was defined in terms of arteriolar bifurcation angles and junction exponents (a measure of the relative diameters of parent and daughter vessels), measured from photographic diapositives using operator-directed image analysis. RESULTS: Members of low-birth-weight groups had significantly narrower bifurcation angles than did members of high-birth-weight groups (74 +/- 1 degree versus 78 +/- 1 degree, P= 0.017 by analysis of variance). There was no significant difference between angles in members of groups with high and low blood pressures. Neither birth weight nor blood pressure grouping affected junction exponents. CONCLUSIONS: Narrower bifurcation angles are associated with increased circulatory energy costs and may be related to a lower than normal microvascular density. Our finding of differences in retinal microvascular architecture might reflect a persistent alteration in vascular architecture as a result of an impairment of foetal development and could provide a mechanistic link between low birth weight and subsequently increased cardiovascular risk.
0263-6352
1449-1453
Chapman, N.
3499de10-fff3-4292-8cd2-b920c6bc70f4
Mohamudally, A.
e1ca8c6d-c35b-431e-81aa-76548c79c3da
Cerutti, A.
9adde68d-3d0d-4aba-8a2b-af6eda012a1d
Stanton, A.
58e57cdf-c55b-47f9-a17a-797fbee81f23
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Barker, D.
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Rauf, A.
6803576a-5bac-4a60-a2b6-250b96a89fb7
Evans, J.
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Wormald, R.
0ebb5403-ffc6-406a-93fa-5556be70c0e9
Sever, P.
05bd5b08-ec0e-4e72-a591-028f1b4f2590
Hughes, A.
a44a626e-46fc-4e6b-9df1-815b1062b950
Thom, S.
04d77951-7c5f-4c3d-b944-5f3394ee48e9
Chapman, N.
3499de10-fff3-4292-8cd2-b920c6bc70f4
Mohamudally, A.
e1ca8c6d-c35b-431e-81aa-76548c79c3da
Cerutti, A.
9adde68d-3d0d-4aba-8a2b-af6eda012a1d
Stanton, A.
58e57cdf-c55b-47f9-a17a-797fbee81f23
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Barker, D.
4da1905f-11d2-4673-b261-1895f6455e2b
Rauf, A.
6803576a-5bac-4a60-a2b6-250b96a89fb7
Evans, J.
f551701f-0ce1-4816-8a77-5a87eaf721a3
Wormald, R.
0ebb5403-ffc6-406a-93fa-5556be70c0e9
Sever, P.
05bd5b08-ec0e-4e72-a591-028f1b4f2590
Hughes, A.
a44a626e-46fc-4e6b-9df1-815b1062b950
Thom, S.
04d77951-7c5f-4c3d-b944-5f3394ee48e9

Chapman, N., Mohamudally, A., Cerutti, A., Stanton, A., Sayer, A.A., Cooper, C., Barker, D., Rauf, A., Evans, J., Wormald, R., Sever, P., Hughes, A. and Thom, S. (1997) Retinal vascular network architecture in low birth-weight men. Journal of Hypertension, 15 (1), 1449-1453.

Record type: Article

Abstract

BACKGROUND: Low birth weight is associated with hypertension and increased cardiovascular mortality, but the mechanism of this association is not known. Hypertension is accompanied by abnormalities of the microvasculature including rarefaction. OBJECTIVE: To test the hypothesis that low birth weight is associated with an alteration in microvascular architecture. DESIGN: A stratified random sample of 100 men aged 64-74 years was selected from a cohort of men whose birth weights were known. They were of relatively high or low birth weight ('high' > or = 3700 g, 'low' < or = 3200 g) and high or low systolic blood pressure (high > or = 160 mmHg, low < or = 140 mmHg). METHODS: Retinal arteriolar geometry was defined in terms of arteriolar bifurcation angles and junction exponents (a measure of the relative diameters of parent and daughter vessels), measured from photographic diapositives using operator-directed image analysis. RESULTS: Members of low-birth-weight groups had significantly narrower bifurcation angles than did members of high-birth-weight groups (74 +/- 1 degree versus 78 +/- 1 degree, P= 0.017 by analysis of variance). There was no significant difference between angles in members of groups with high and low blood pressures. Neither birth weight nor blood pressure grouping affected junction exponents. CONCLUSIONS: Narrower bifurcation angles are associated with increased circulatory energy costs and may be related to a lower than normal microvascular density. Our finding of differences in retinal microvascular architecture might reflect a persistent alteration in vascular architecture as a result of an impairment of foetal development and could provide a mechanistic link between low birth weight and subsequently increased cardiovascular risk.

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Published date: December 1997

Identifiers

Local EPrints ID: 159739
URI: https://eprints.soton.ac.uk/id/eprint/159739
ISSN: 0263-6352
PURE UUID: dc6da160-959a-4ea9-ba53-f2df7dd41155
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 07 Jul 2010 15:50
Last modified: 31 Jul 2019 00:49

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Contributors

Author: N. Chapman
Author: A. Mohamudally
Author: A. Cerutti
Author: A. Stanton
Author: A.A. Sayer
Author: C. Cooper ORCID iD
Author: D. Barker
Author: A. Rauf
Author: J. Evans
Author: R. Wormald
Author: P. Sever
Author: A. Hughes
Author: S. Thom

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