Microelectrode investigation of neuroneal ageing from a single identified neurone
Microelectrode investigation of neuroneal ageing from a single identified neurone
Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamine neurotransmitter serotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.
10065-10072
Patel, B.
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Arundell, Martin
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Parker, Kim H.
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Yeoman, Mark S.
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O'Hare, Danny
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12 July 2010
Patel, B.
fb5c89c9-47ce-42d1-8f22-2ab394ffac0d
Arundell, Martin
e24d3405-a436-4d65-a6e4-2939ede79678
Parker, Kim H.
9e87c3a6-5f17-4681-ba96-2c62f2817fb5
Yeoman, Mark S.
0f313a79-c8f9-4b0e-8c95-6321ad5c52b2
O'Hare, Danny
7c94a94e-383c-45de-9d89-cba323416c6b
Patel, B., Arundell, Martin, Parker, Kim H., Yeoman, Mark S. and O'Hare, Danny
(2010)
Microelectrode investigation of neuroneal ageing from a single identified neurone.
Physical Chemistry Chemical Physics, 12, .
(doi:10.1039/c0cp00310g).
Abstract
Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamine neurotransmitter serotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.
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Published date: 12 July 2010
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Local EPrints ID: 160315
URI: http://eprints.soton.ac.uk/id/eprint/160315
ISSN: 1463-9076
PURE UUID: 80ee016f-fb40-406f-8024-2e5b1b4c1a3a
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Date deposited: 20 Jul 2010 10:28
Last modified: 14 Mar 2024 01:57
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Contributors
Author:
B. Patel
Author:
Kim H. Parker
Author:
Mark S. Yeoman
Author:
Danny O'Hare
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