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Microelectrode investigation of neuroneal ageing from a single identified neurone

Patel, B., Arundell, Martin, Parker, Kim H., Yeoman, Mark S. and O'Hare, Danny (1970) Microelectrode investigation of neuroneal ageing from a single identified neurone Physical Chemistry Chemical Physics, 12, pp. 10065-10072. (doi:10.1039/c0cp00310g).

Record type: Article


Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamine neurotransmitter serotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

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Published date: 1 January 1970


Local EPrints ID: 160315
ISSN: 1463-9076
PURE UUID: 80ee016f-fb40-406f-8024-2e5b1b4c1a3a

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Date deposited: 20 Jul 2010 10:28
Last modified: 18 Jul 2017 12:35

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Author: B. Patel
Author: Martin Arundell
Author: Kim H. Parker
Author: Mark S. Yeoman
Author: Danny O'Hare

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