Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol.
Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol.
We are presently aware of two early-phase DNA vaccine clinical trials in humans using electroporation-enhanced vaccine delivery. Moreover, two phase I immunogenetherapy studies are in progress and several tolerability studies have been performed on healthy volunteers. We have used knowledge from these studies to compose a template for clinical protocols involving electroporation-mediated gene delivery. In this template the emphasis will be on aspects related to electroporation. In addition, we will discuss general topics concerning electroporation-augmented DNA vaccination in human subjects.
clinical trial, electroporation, electroporation device, dna vaccination
497-507
Tjelle, Torunn Elisabeth
6c26b1a8-d137-4668-aabb-4e49493cf0b2
Rabussay, Dietmar
49021c0b-8dbe-4833-8c94-30bc8ba72837
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Mathiesen, Iacob
fd96fb25-21e0-411d-b4b5-f2a3169de8ae
Kjeken, Rune
ff896879-ef64-44ad-8cbf-00853e073025
28 March 2008
Tjelle, Torunn Elisabeth
6c26b1a8-d137-4668-aabb-4e49493cf0b2
Rabussay, Dietmar
49021c0b-8dbe-4833-8c94-30bc8ba72837
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Mathiesen, Iacob
fd96fb25-21e0-411d-b4b5-f2a3169de8ae
Kjeken, Rune
ff896879-ef64-44ad-8cbf-00853e073025
Tjelle, Torunn Elisabeth, Rabussay, Dietmar, Ottensmeier, Christian, Mathiesen, Iacob and Kjeken, Rune
(2008)
Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol.
Methods in Molecular Biology, 423, part VI, .
(doi:10.1007/978-1-59745-194-9_39).
Abstract
We are presently aware of two early-phase DNA vaccine clinical trials in humans using electroporation-enhanced vaccine delivery. Moreover, two phase I immunogenetherapy studies are in progress and several tolerability studies have been performed on healthy volunteers. We have used knowledge from these studies to compose a template for clinical protocols involving electroporation-mediated gene delivery. In this template the emphasis will be on aspects related to electroporation. In addition, we will discuss general topics concerning electroporation-augmented DNA vaccination in human subjects.
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More information
Published date: 28 March 2008
Keywords:
clinical trial, electroporation, electroporation device, dna vaccination
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Local EPrints ID: 160903
URI: http://eprints.soton.ac.uk/id/eprint/160903
PURE UUID: e3120286-7f2d-4e0a-be7f-90e0c4689851
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Date deposited: 21 Jul 2010 10:36
Last modified: 14 Mar 2024 01:58
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Contributors
Author:
Torunn Elisabeth Tjelle
Author:
Dietmar Rabussay
Author:
Iacob Mathiesen
Author:
Rune Kjeken
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