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Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol.

Tjelle, Torunn Elisabeth, Rabussay, Dietmar, Ottensmeier, Christian, Mathiesen, Iacob and Kjeken, Rune (2008) Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol. Methods in Molecular Biology, 423, part VI, pp. 497-507. (doi:10.1007/978-1-59745-194-9_39).

Record type: Article

Abstract

We are presently aware of two early-phase DNA vaccine clinical trials in humans using electroporation-enhanced vaccine delivery. Moreover, two phase I immunogenetherapy studies are in progress and several tolerability studies have been performed on healthy volunteers. We have used knowledge from these studies to compose a template for clinical protocols involving electroporation-mediated gene delivery. In this template the emphasis will be on aspects related to electroporation. In addition, we will discuss general topics concerning electroporation-augmented DNA vaccination in human subjects.

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More information

Published date: 28 March 2008
Keywords: clinical trial, electroporation, electroporation device, dna vaccination

Identifiers

Local EPrints ID: 160903
URI: http://eprints.soton.ac.uk/id/eprint/160903
PURE UUID: e3120286-7f2d-4e0a-be7f-90e0c4689851

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Date deposited: 21 Jul 2010 10:36
Last modified: 18 Jul 2017 12:34

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Contributors

Author: Torunn Elisabeth Tjelle
Author: Dietmar Rabussay
Author: Iacob Mathiesen
Author: Rune Kjeken

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