Maternal diet, behaviour and offspring skeletal health
Maternal diet, behaviour and offspring skeletal health
Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.
osteoporosis, epigenetic, early life origins, fracture, bone mass, vitamin D, neonate, fetus
1760-1772
Goodfellow, Laura R.
1afe18d7-de8b-42e1-8909-d7c0ff5f00cc
Earl, Susannah
23a453f9-0a79-4595-b7ed-22f90ac03c04
Cooper, Cyrus
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
April 2010
Goodfellow, Laura R.
1afe18d7-de8b-42e1-8909-d7c0ff5f00cc
Earl, Susannah
23a453f9-0a79-4595-b7ed-22f90ac03c04
Cooper, Cyrus
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Goodfellow, Laura R., Earl, Susannah, Cooper, Cyrus and Harvey, Nicholas C.
(2010)
Maternal diet, behaviour and offspring skeletal health.
International Journal of Environmental Research and Public Health, 7 (4), .
(doi:10.3390/ijerph7041760).
Abstract
Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.
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Published date: April 2010
Keywords:
osteoporosis, epigenetic, early life origins, fracture, bone mass, vitamin D, neonate, fetus
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Local EPrints ID: 161115
URI: http://eprints.soton.ac.uk/id/eprint/161115
ISSN: 1660-4601
PURE UUID: 2569671f-b334-4679-a847-30a8943fd503
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Date deposited: 23 Jul 2010 11:13
Last modified: 14 Mar 2024 02:49
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Author:
Laura R. Goodfellow
Author:
Susannah Earl
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