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Maternal diet, behaviour and offspring skeletal health

Goodfellow, Laura R., Earl, Susannah, Cooper, Cyrus and Harvey, Nicholas C. (2010) Maternal diet, behaviour and offspring skeletal health International Journal of Environmental Research and Public Health, 7, (4), pp. 1760-1772.

Record type: Article

Abstract

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.

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More information

Published date: April 2010
Keywords: osteoporosis, epigenetic, early life origins, fracture, bone mass, vitamin D, neonate, fetus

Identifiers

Local EPrints ID: 161115
URI: http://eprints.soton.ac.uk/id/eprint/161115
ISSN: 1660-4601
PURE UUID: 2569671f-b334-4679-a847-30a8943fd503
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 23 Jul 2010 11:13
Last modified: 24 Aug 2017 02:32

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Contributors

Author: Laura R. Goodfellow
Author: Susannah Earl
Author: Cyrus Cooper ORCID iD

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