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Potential therapeutic uses for ezetimibe beyond lowering LDL-c to decrease cardiovascular events

Potential therapeutic uses for ezetimibe beyond lowering LDL-c to decrease cardiovascular events
Potential therapeutic uses for ezetimibe beyond lowering LDL-c to decrease cardiovascular events
Ezetimibe is a relatively new drug that inhibits the absorption of dietary cholesterol in the small intestine. It is an LDL-cholesterol lowering medication that acts directly on the intestine by inhibiting Niemann-Pick C1 Like1 (NPC1L1). Recently, results of the ARBITER 6–HALTS trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6–HDL and LDL Treatment Strategies) and the ENHANCE trial (Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression) showed that ezetimibe had no effect on atherosclerosis despite producing a marked decrease in low density lipoprotein cholesterol (LDL-c). Recent studies show a potential benefit of ezetimibe in treating insulin resistance, non-alcoholic fatty liver disease, gallstones and dyslipidaemia associated with chronic renal failure and organ transplantation. All of these conditions are known to be associated with an increase in risk of cardiovascular disease and further studies are needed to assess the potential benefits of ezetimibe in these therapeutics areas.
ezetimibe, non alcoholic fatty liver disease, insulin resistance, gallstones, cardiovascular disease
1462-8902
958-966
Ahmed, M.H.
0dcfcd8b-55bc-48dc-9dbe-24df7fe58269
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Ahmed, M.H.
0dcfcd8b-55bc-48dc-9dbe-24df7fe58269
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c

Ahmed, M.H. and Byrne, Christopher D. (2010) Potential therapeutic uses for ezetimibe beyond lowering LDL-c to decrease cardiovascular events. Diabetes, Obesity and Metabolism, 12 (11), 958-966. (doi:10.1111/j.1463-1326.2010.01261.x). (PMID:20880342)

Record type: Article

Abstract

Ezetimibe is a relatively new drug that inhibits the absorption of dietary cholesterol in the small intestine. It is an LDL-cholesterol lowering medication that acts directly on the intestine by inhibiting Niemann-Pick C1 Like1 (NPC1L1). Recently, results of the ARBITER 6–HALTS trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6–HDL and LDL Treatment Strategies) and the ENHANCE trial (Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression) showed that ezetimibe had no effect on atherosclerosis despite producing a marked decrease in low density lipoprotein cholesterol (LDL-c). Recent studies show a potential benefit of ezetimibe in treating insulin resistance, non-alcoholic fatty liver disease, gallstones and dyslipidaemia associated with chronic renal failure and organ transplantation. All of these conditions are known to be associated with an increase in risk of cardiovascular disease and further studies are needed to assess the potential benefits of ezetimibe in these therapeutics areas.

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Published date: November 2010
Keywords: ezetimibe, non alcoholic fatty liver disease, insulin resistance, gallstones, cardiovascular disease

Identifiers

Local EPrints ID: 161533
URI: http://eprints.soton.ac.uk/id/eprint/161533
ISSN: 1462-8902
PURE UUID: f7271270-3a6b-4a85-8981-ede00d6297a4
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 30 Jul 2010 15:19
Last modified: 29 Oct 2019 01:58

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