The University of Southampton
University of Southampton Institutional Repository

Systematic reviews of adverse effects of drug interventions: a survey of their conduct and reporting quality

Cornelius, V.R., Perrio, M.J., Shakir, A.W. and Smith, L.A. (2009) Systematic reviews of adverse effects of drug interventions: a survey of their conduct and reporting quality Pharmacoepidemiology and Drug Safety, 18, (12), pp. 1223-1231. (doi:10.1002/pds.1844).

Record type: Article

Abstract

Purpose: There is a need for high quality evidence on the adverse effects of medical interventions to inform policy, practice and research.

Methods to systematically review adverse effects have not been fully developed.We aimed to assess the current methods and reporting used by
such reviews.

Methods: Survey of general medical, drug safety and pharmacology journals published in 2006. Methods including: searching, inclusion criteria, quality assessment and meta-analysis were assessed.

Results: Forty three systematic reviews from 2704 abstracts in 16 journals were included. The search strategy was not reported by 10 (23%) of reviews. The collection and reporting of the adverse effects from primary studies was described by 4/37 (12%) reviews and the quality of included studies was assessed by 15 (35%) of reviews. Meta-analysis on rare outcomes and handing of zero event data were inconsistent. A polarity in the standard of reporting between reviews was observed. The reporting standard we found was similar to another survey of systematic reviews.

Conclusion: Reporting was poor with respect to searching and definition/collection of adverse effects and guidelines such as QUOROM and MOOSE could be employed by authors. Comprehensive and clear reporting should be enforced by journals. The low proportion of reviews
assessing quality, and the inconsistencies observed when modelling rare event data reflect the need for empirical research to underpin methods in these areas.

Full text not available from this repository.

More information

Published date: 15 September 2009
Keywords: systematic review, adverse effects, reporting, quality, meta-analysis, rare

Identifiers

Local EPrints ID: 162013
URI: http://eprints.soton.ac.uk/id/eprint/162013
ISSN: 1053-8569
PURE UUID: b4b13541-7534-4eba-998f-e3f14c238ecc

Catalogue record

Date deposited: 12 Aug 2010 10:45
Last modified: 18 Jul 2017 12:33

Export record

Altmetrics

Contributors

Author: V.R. Cornelius
Author: M.J. Perrio
Author: A.W. Shakir
Author: L.A. Smith

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×