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Reference values for nerve function assessments among a study population in northern India - I. Vibration perception thresholds

Reference values for nerve function assessments among a study population in northern India - I. Vibration perception thresholds
Reference values for nerve function assessments among a study population in northern India - I. Vibration perception thresholds
Objective: this paper presents normal reference values for vibration perception thresholds for a study population in northern India. The work was in preparation for the INFIR Cohort Study, a prospective study of people newly diagnosed with multibacillary leprosy which sought to identify early changes in nerve function predictive of new onset impairment and reactions. To establish the limits of normal
function we collected data on subjects with no known neurological condition and computed the reference
values defining the limits of normal function.

Methods: data on vibration perception in 5 bilateral nerves was collected from 362 healthy subjects stratified by sex and by age and drawn from the same general population as the subsequent leprosy-affected cohort. Reference values were computed from log-transformed data after the exclusion of outliers.

Results: normal reference values are presented in the form of 95th percentiles for vibration perception thresholds among normal subjects for 5 peripheral nerves within 8 age and sex groupings and by centre. The reference values are compared with those published for other populations. The incidence of impairment at diagnosis among the leprosy-affected cohort is described and illustrated
1823-6138
129-139
Nicholls, P.G.
b569acda-01e1-4022-93ef-efce28ea7ddd
McKnight, J.
4e7c84b8-74f3-4552-a189-7dc1c05d5341
Loretta, Das
360983b4-3d01-430d-8c90-12dc63ff1a05
Desikan, K.V.
7b73a83d-fac6-4c6b-a502-13dfcc379d2b
Lockwood, D.N.J.
075da765-b070-4e35-aa82-84ead70f22f1
Wilder-Smith, E.P.
7c598074-d4f0-4320-ad87-3c5a6ff0b25c
van Brakel, W.H.
6786a823-d23c-4af0-8108-5a8c86c419cc
Nicholls, P.G.
b569acda-01e1-4022-93ef-efce28ea7ddd
McKnight, J.
4e7c84b8-74f3-4552-a189-7dc1c05d5341
Loretta, Das
360983b4-3d01-430d-8c90-12dc63ff1a05
Desikan, K.V.
7b73a83d-fac6-4c6b-a502-13dfcc379d2b
Lockwood, D.N.J.
075da765-b070-4e35-aa82-84ead70f22f1
Wilder-Smith, E.P.
7c598074-d4f0-4320-ad87-3c5a6ff0b25c
van Brakel, W.H.
6786a823-d23c-4af0-8108-5a8c86c419cc

Nicholls, P.G., McKnight, J., Loretta, Das, Desikan, K.V., Lockwood, D.N.J., Wilder-Smith, E.P. and van Brakel, W.H. (2009) Reference values for nerve function assessments among a study population in northern India - I. Vibration perception thresholds. Neurology Asia, 14 (2), 129-139.

Record type: Article

Abstract

Objective: this paper presents normal reference values for vibration perception thresholds for a study population in northern India. The work was in preparation for the INFIR Cohort Study, a prospective study of people newly diagnosed with multibacillary leprosy which sought to identify early changes in nerve function predictive of new onset impairment and reactions. To establish the limits of normal
function we collected data on subjects with no known neurological condition and computed the reference
values defining the limits of normal function.

Methods: data on vibration perception in 5 bilateral nerves was collected from 362 healthy subjects stratified by sex and by age and drawn from the same general population as the subsequent leprosy-affected cohort. Reference values were computed from log-transformed data after the exclusion of outliers.

Results: normal reference values are presented in the form of 95th percentiles for vibration perception thresholds among normal subjects for 5 peripheral nerves within 8 age and sex groupings and by centre. The reference values are compared with those published for other populations. The incidence of impairment at diagnosis among the leprosy-affected cohort is described and illustrated

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Published date: December 2009

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Local EPrints ID: 162223
URI: http://eprints.soton.ac.uk/id/eprint/162223
ISSN: 1823-6138
PURE UUID: e8b3ae8b-8b6f-43c5-a5d0-303e17b68555

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Date deposited: 16 Aug 2010 14:05
Last modified: 16 Jul 2019 23:53

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