The University of Southampton
University of Southampton Institutional Repository

MEG's ability to localise accurately weak transient neural sources

Record type: Article

Objective: to investigate the accurate localisation of weak, transient, neural sources under conditions of varying difficulty.

Methods: multiple dipolar sources placed within a head-shaped phantom at superficial and deep locations were driven separately or simultaneously by a short-lasting current with varied amplitudes. Artificial MEG signals that were very similar to the human High Frequency Oscillations (HFO) were produced. MEG signals of HFO were also recorded from median nerve stimulation. Different inverse techniques were used to localise the phantom dipoles and the human HFO generators.

Results: the human HFO were measured around 200 and 600 Hz by using only 120 trials. The 200 Hz HFO were localised to BA3b. The superficial phantom’s source was localised with an accuracy of 2–3 mm by all inverse techniques (120 trials). The ‘subcortical’ source was localised with an error of 5 mm. Localisation of deeper ‘thalamic’ sources required more trials.

Conclusion: MEG can detect and localise weak transient activations and the human HFO with an accuracy of a few mm at cortical and subcortical regions even when a small number of trials are used.

Significance: localizing HFO to specific anatomical structures has high clinical utility, for example in epilepsy, where discrete HFO appears to be generated just before focal epileptic activity


Full text not available from this repository.

Citation

Papadelis, C., Poghosyan, V., Fenwick, P. and Ioannides, A.A. (2009) MEG's ability to localise accurately weak transient neural sources Clinical Neurophysiology, 120, (11), pp. 1958-1970. (doi:10.1016/j.clinph.2009.08.018).

More information

Published date: November 2009

Identifiers

Local EPrints ID: 162381
URI: http://eprints.soton.ac.uk/id/eprint/162381
PURE UUID: 2770d904-ee34-4f36-88c4-cc56c2ca5b2c

Catalogue record

Date deposited: 20 Aug 2010 08:36
Last modified: 18 Jul 2017 12:32

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×