Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart
Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart
Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100 g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease.
heart, fatty acids, phophospholipids, triacylglycerol, sex, rat
219-223
Slater-Jefferies, Joanne L.
e46c711a-9d4c-436a-b853-828df69bb4d7
Hoile, Samuel P.
9d7e9816-600d-45bd-ade2-dc7798bba730
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
October 2010
Slater-Jefferies, Joanne L.
e46c711a-9d4c-436a-b853-828df69bb4d7
Hoile, Samuel P.
9d7e9816-600d-45bd-ade2-dc7798bba730
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Slater-Jefferies, Joanne L., Hoile, Samuel P., Lillycrop, Karen A., Townsend, Paul A., Hanson, Mark A. and Burdge, Graham C.
(2010)
Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart.
Prostaglandins, Leukotrienes and Essential Fatty Acids, 83 (4-6), .
(doi:10.1016/j.plefa.2010.07.006).
(PMID:20719489)
Abstract
Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100 g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease.
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Accepted/In Press date: 16 August 2010
Published date: October 2010
Keywords:
heart, fatty acids, phophospholipids, triacylglycerol, sex, rat
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Local EPrints ID: 162457
URI: http://eprints.soton.ac.uk/id/eprint/162457
PURE UUID: c7517db2-de51-456d-a37d-df0022bf8114
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Date deposited: 20 Aug 2010 15:17
Last modified: 14 Mar 2024 02:51
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Author:
Samuel P. Hoile
Author:
Paul A. Townsend
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