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Programmed assembly of peptide-functionalized gold nanoparticles on DNA templates

Programmed assembly of peptide-functionalized gold nanoparticles on DNA templates
Programmed assembly of peptide-functionalized gold nanoparticles on DNA templates
We present a novel nanoparticle building block system based on the interactions between short synthetic oligonucleotides and peptides. Gold nanoparticles coated with DNA-binding peptides can be attached to self-organized oligonucleotide templates to formulate well-ordered structures of nanoparticles. By regulating the amount of DNA-binding peptide attached to the nanoparticle surface and using specifically designed oligonucleotides, the nanoparticle assembly can be controlled to form dimers, trimers, and adjustable-length nanoparticle chains as well as more complex structures.
0743-7463
13760-13762
Coomber, Danielle
9f633247-884f-48a2-abfb-1f82e9f435c9
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Gerrard, Simon R.
4ed7b304-42c2-497a-b00d-5ac8a1bedd24
Tyas, Sarah
3162c2b4-53e2-44e5-8304-69d9556d5999
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Coomber, Danielle
9f633247-884f-48a2-abfb-1f82e9f435c9
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Gerrard, Simon R.
4ed7b304-42c2-497a-b00d-5ac8a1bedd24
Tyas, Sarah
3162c2b4-53e2-44e5-8304-69d9556d5999
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d

Coomber, Danielle, Bartczak, Dorota, Gerrard, Simon R., Tyas, Sarah, Kanaras, Antonios G. and Stulz, Eugen (2010) Programmed assembly of peptide-functionalized gold nanoparticles on DNA templates. Langmuir, 26 (17), 13760-13762. (doi:10.1021/la1023554). (PMID:20672816)

Record type: Article

Abstract

We present a novel nanoparticle building block system based on the interactions between short synthetic oligonucleotides and peptides. Gold nanoparticles coated with DNA-binding peptides can be attached to self-organized oligonucleotide templates to formulate well-ordered structures of nanoparticles. By regulating the amount of DNA-binding peptide attached to the nanoparticle surface and using specifically designed oligonucleotides, the nanoparticle assembly can be controlled to form dimers, trimers, and adjustable-length nanoparticle chains as well as more complex structures.

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More information

e-pub ahead of print date: 30 July 2010
Published date: 7 September 2010
Organisations: Organic Chemistry: SCF

Identifiers

Local EPrints ID: 162523
URI: http://eprints.soton.ac.uk/id/eprint/162523
ISSN: 0743-7463
PURE UUID: 23ad3f79-ba99-4c75-80de-71cd4d2b2c6b
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706
ORCID for Eugen Stulz: ORCID iD orcid.org/0000-0002-5302-2276

Catalogue record

Date deposited: 23 Aug 2010 15:22
Last modified: 14 Mar 2024 02:53

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Contributors

Author: Danielle Coomber
Author: Dorota Bartczak
Author: Simon R. Gerrard
Author: Sarah Tyas
Author: Eugen Stulz ORCID iD

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