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Effects of AEDs on biomarkers in people with epilepsy: CRP, HbA1c and eGFR

Effects of AEDs on biomarkers in people with epilepsy: CRP, HbA1c and eGFR
Effects of AEDs on biomarkers in people with epilepsy: CRP, HbA1c and eGFR
The standardised mortality ratio in people with epilepsy is raised to between 2 and 3 compared with the general population. Some biomarker levels, including higher C-reactive protein (CRP), higher glycosylated haemoglobin (HbA1c) and lower estimated glomerular filtration rate (eGFR), are associated with an increase risk of premature mortality. These biomarkers were measured in 125 people with refractory epilepsy to estimate the potential effect of antiepileptic drug (AED) use on these markers. Multiple regression analysis showed that valproate (N = 50) use was associated with 55% lower mean CRP concentrations and higher mean eGFR values; and phenytoin (N = 32) use with 4% lower mean HbA1c values. These potentially represent health markers improved by AEDs. On the other hand, lamotrigine use (N = 48) was associated with 13% lower mean eGFR and this may represent a negative effect on a health marker. These preliminary observations clearly require further controlled studies ideally in people on AED monotherapy.
antiepileptic drugs, biomarkers, c-reactive protein, hbA1c, egfr
0920-1211
Yuen, Alan W.C.
0b44745a-1a17-4cb5-af9d-aed2cc24d128
Bell, Gail S.
90937dc3-6df6-4a3e-b34b-dfa6bb49c495
Peacock, Janet
62df4239-ae7e-44cf-aa3c-3c2e7f1e511c
Koepp, Matthias M.
da7ee970-cf15-4896-a22d-face8a7c7f08
Patsalos, Phillip N.
c8de356f-dbb4-405d-a7d7-a1da26645a4b
Sander, Josemir W.
f226e78c-840e-4a97-b66e-03911cd9f640
Yuen, Alan W.C.
0b44745a-1a17-4cb5-af9d-aed2cc24d128
Bell, Gail S.
90937dc3-6df6-4a3e-b34b-dfa6bb49c495
Peacock, Janet
62df4239-ae7e-44cf-aa3c-3c2e7f1e511c
Koepp, Matthias M.
da7ee970-cf15-4896-a22d-face8a7c7f08
Patsalos, Phillip N.
c8de356f-dbb4-405d-a7d7-a1da26645a4b
Sander, Josemir W.
f226e78c-840e-4a97-b66e-03911cd9f640

Yuen, Alan W.C., Bell, Gail S., Peacock, Janet, Koepp, Matthias M., Patsalos, Phillip N. and Sander, Josemir W. (2010) Effects of AEDs on biomarkers in people with epilepsy: CRP, HbA1c and eGFR. Epilepsy Research. (doi:10.1016/j.eplepsyres.2010.07.011). (In Press)

Record type: Article

Abstract

The standardised mortality ratio in people with epilepsy is raised to between 2 and 3 compared with the general population. Some biomarker levels, including higher C-reactive protein (CRP), higher glycosylated haemoglobin (HbA1c) and lower estimated glomerular filtration rate (eGFR), are associated with an increase risk of premature mortality. These biomarkers were measured in 125 people with refractory epilepsy to estimate the potential effect of antiepileptic drug (AED) use on these markers. Multiple regression analysis showed that valproate (N = 50) use was associated with 55% lower mean CRP concentrations and higher mean eGFR values; and phenytoin (N = 32) use with 4% lower mean HbA1c values. These potentially represent health markers improved by AEDs. On the other hand, lamotrigine use (N = 48) was associated with 13% lower mean eGFR and this may represent a negative effect on a health marker. These preliminary observations clearly require further controlled studies ideally in people on AED monotherapy.

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More information

Accepted/In Press date: 18 July 2010
Keywords: antiepileptic drugs, biomarkers, c-reactive protein, hbA1c, egfr

Identifiers

Local EPrints ID: 162581
URI: http://eprints.soton.ac.uk/id/eprint/162581
ISSN: 0920-1211
PURE UUID: 60bb2d71-f351-4680-8d0b-86cd8a875683

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Date deposited: 24 Aug 2010 12:47
Last modified: 14 Mar 2024 02:03

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Contributors

Author: Alan W.C. Yuen
Author: Gail S. Bell
Author: Janet Peacock
Author: Matthias M. Koepp
Author: Phillip N. Patsalos
Author: Josemir W. Sander

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