Intraoperative assessment of sentinel lymph nodes in breast cancer
Intraoperative assessment of sentinel lymph nodes in breast cancer
Background: Sentinel lymph node biopsy (SLNB) reduces the morbidity of axillary clearance and is the standard of care for patients with clinically node-negative breast cancer. The ability to analyse the sentinel node during surgery enables a decision to be made whether to proceed to full axillary clearance during primary surgery, thus avoiding a second procedure in node-positive patients.
Methods: Current evidence for intraoperative sentinel node analysis following SLNB in breast cancer was reviewed and evaluated, based on articles obtained from a MEDLINE search using the terms ‘sentinel node’, ‘intra-operative’ and ‘breast cancer’.
Results and conclusion: Current methods for evaluating the sentinel node during surgery include cytological and histological techniques. Newer quantitative molecular assays have been the subject of much recent clinical research. Pathological techniques of intraoperative SLNB analysis such as touch imprint cytology and frozen section have a high specificity, but a lower and more variably reported sensitivity. Molecular techniques are potentially able to sample a greater proportion of the sentinel node, and could have higher sensitivity.
Layfield, D.M.
b95c7cdb-ef01-4c36-b9cc-9b43ab17af61
Agrawal, A.
6f9fe130-fc73-4d92-8052-967879ae7810
Roche, H.
38f34478-2d40-40c7-86b7-5b5a6e888418
Cutress, R.I.
68ae4f86-e8cf-411f-a335-cdba51797406
1 September 2010
Layfield, D.M.
b95c7cdb-ef01-4c36-b9cc-9b43ab17af61
Agrawal, A.
6f9fe130-fc73-4d92-8052-967879ae7810
Roche, H.
38f34478-2d40-40c7-86b7-5b5a6e888418
Cutress, R.I.
68ae4f86-e8cf-411f-a335-cdba51797406
Layfield, D.M., Agrawal, A., Roche, H. and Cutress, R.I.
(2010)
Intraoperative assessment of sentinel lymph nodes in breast cancer.
British Journal of Surgery.
(doi:10.1002/bjs.7229).
Abstract
Background: Sentinel lymph node biopsy (SLNB) reduces the morbidity of axillary clearance and is the standard of care for patients with clinically node-negative breast cancer. The ability to analyse the sentinel node during surgery enables a decision to be made whether to proceed to full axillary clearance during primary surgery, thus avoiding a second procedure in node-positive patients.
Methods: Current evidence for intraoperative sentinel node analysis following SLNB in breast cancer was reviewed and evaluated, based on articles obtained from a MEDLINE search using the terms ‘sentinel node’, ‘intra-operative’ and ‘breast cancer’.
Results and conclusion: Current methods for evaluating the sentinel node during surgery include cytological and histological techniques. Newer quantitative molecular assays have been the subject of much recent clinical research. Pathological techniques of intraoperative SLNB analysis such as touch imprint cytology and frozen section have a high specificity, but a lower and more variably reported sensitivity. Molecular techniques are potentially able to sample a greater proportion of the sentinel node, and could have higher sensitivity.
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Published date: 1 September 2010
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Local EPrints ID: 163121
URI: http://eprints.soton.ac.uk/id/eprint/163121
PURE UUID: bd405988-8c15-4468-92e4-17eafbea2a62
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Date deposited: 03 Sep 2010 12:17
Last modified: 14 Mar 2024 02:04
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Author:
D.M. Layfield
Author:
A. Agrawal
Author:
H. Roche
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