Outcomes in patients on home haemodialysis in England and Wales, 1997–2005: a comparative cohort analysis

Nitsch, Dorothea, Steenkamp, Retha, Tomson, Charles R.V., Roderick, Paul, Ansell, David and MacGregor, Mark S. (2011) Outcomes in patients on home haemodialysis in England and Wales, 1997–2005: a comparative cohort analysis. Nephrology, Dialysis, Transplantation, 26 (5), 1670-1677. (doi:10.1093/ndt/gfq561).

Abstract

Background: The UK national policy promotes expansion of home haemodialysis, but there are no recent data on characteristics and outcomes of a national home haemodialysis population.

Methods: We compared incident home haemodialysis patients in England and Wales (n = 225, 1997–2005) with age- and sex-matched incident peritoneal dialysis, hospital haemodialysis and satellite haemodialysis patients with follow-up until 31 December 2006. Cox regression analyses included time-dependent changes of wait-listing for transplantation (a proxy for health status), start of home haemodialysis and transplantation.

Results: There was a median delay of 12 months between starting renal replacement therapy (RRT) and home haemodialysis. During that first year of RRT, >?50% of home haemodialysis patients were wait-listed for kidney transplantation; hospital haemodialysis patients had a lower rate of wait-listing over time [hazard ratio (HR) 0.56, 95% confidence interval (CI) 0.44–0.70; P < 0.001]. In crude analyses, there was a marked survival advantage of home haemodialysis patients compared with other modalities (log-rank P-value < 0.001). In adjusted analyses, being on home haemodialysis yielded a long-term survival benefit compared with peritoneal dialysis (HR 0.61, 95% CI 0.40–0.93), and a borderline advantage compared with hospital haemodialysis (HR 0.68, 95% CI 0.44–1.03). There was no evidence of an advantage compared with satellite haemodialysis (HR 0.94, 95% CI 0.65–1.37).

Conclusions: Home haemodialysis patients have better survival compared with other dialysis modalities. Some of this crude survival advantage is due to selection of a healthier patient cohort as evidenced by higher transplant wait-listing rates. The advantage over peritoneal dialysis persisted after adjustment for wait-listing and transplantation over time.

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Contributors

Author: Paul Roderick

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