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Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women

Adachi, Jonathan .D., Adami, Silvano, Gehlbach, Stephen, Anderson, Frederick A., Boonen, Steven, Chapurlat, Roland D., Compston, Juliet E., Cooper, Cyrus, Delmas, Pierre, Diez-Perez, Adolfo, Greenspan, Susan L., Hooven, Frederick H., Lacroix, Andrea Z., Lindsay, Robert, Netelenbos, J. Coen, Wu, Olivia, Pfeilschifter, Johannes, Roux, Christian, Saag, Kenneth G., Sambrook, Philip N., Silverman, Stuart, Siris, Ethel S., Nika, Grigor and Watts, Nelson B. GLOW Investigators (2010) Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women Mayo Clinic Proceedings, 85, (9), pp. 806-813. (doi:10.4065/?mcp.2010.0082). (PMID:20634496).

Record type: Article


OBJECTIVE: To examine several dimensions of health-related quality of life (HRQL) in postmenopausal women who report previous fractures, and to provide perspective by comparing these findings with those in other chronic conditions (diabetes, arthritis, lung disease).

PATIENTS AND METHODS: Fractures are a major cause of morbidity among older women. Few studies have examined HRQL in women who have had prior fractures and the effect of prior fracture location on HRQL. In this observational study of 57,141 postmenopausal women aged 55 years and older (enrollment from December 2007 to March 2009) from 17 study sites in 10 countries, HRQL was measured using the European Quality of Life 5 Dimensions Index (EQ-5D) and the health status, physical function, and vitality questions of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36).

RESULTS: Reductions in EQ-5D health-utility scores and SF-36–measured health status, physical function, and vitality were seen in association with 9 of 10 fracture locations. Spine, hip, and upper leg fractures resulted in the greatest reductions in quality of life (EQ-5D scores, 0.62, 0.64, and 0.61, respectively, vs 0.79 without prior fracture). Women with fractures at any of these 3 locations, as well as women with a history of multiple fractures (EQ-5D scores, 0.74 for 1 prior fracture, 0.68 for 2, and 0.58 for ?3), had reductions in HRQL that were similar to or worse than those in women with other chronic diseases (0.67 for diabetes, 0.69 for arthritis, and 0.71 for lung disease).

CONCLUSION: Previous fractures at a variety of bone locations, particularly spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life.

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Published date: 15 July 2010


Local EPrints ID: 164133
ISSN: 0025-6196
PURE UUID: ace72e08-ebcf-4003-a7fc-a5933997fdb4
ORCID for Cyrus Cooper: ORCID iD

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Date deposited: 05 Oct 2010 15:33
Last modified: 18 Jul 2017 12:28

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Author: Jonathan .D. Adachi
Author: Silvano Adami
Author: Stephen Gehlbach
Author: Frederick A. Anderson
Author: Steven Boonen
Author: Roland D. Chapurlat
Author: Juliet E. Compston
Author: Cyrus Cooper ORCID iD
Author: Pierre Delmas
Author: Adolfo Diez-Perez
Author: Susan L. Greenspan
Author: Frederick H. Hooven
Author: Andrea Z. Lacroix
Author: Robert Lindsay
Author: J. Coen Netelenbos
Author: Olivia Wu
Author: Johannes Pfeilschifter
Author: Christian Roux
Author: Kenneth G. Saag
Author: Philip N. Sambrook
Author: Stuart Silverman
Author: Ethel S. Siris
Author: Grigor Nika
Author: Nelson B. Watts

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