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Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

Delivani, Petrina, Adrain, Colin, Taylor, Rebecca C., Duriez, Patrick J. and Martin, Seamus J. (2006) Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics Molecular cell, 21, (6), pp. 761-773. (doi:10.1016/j.molcel.2006.01.034). (PMID:16543141).

Record type: Article

Abstract

Bcl-2 family proteins play central roles in apoptosis by regulating the release of mitochondrial intermembrane space proteins such as cytochrome c. Death-promoting Bcl-2 family members, such as Bax, can promote cytochrome c release and fragmentation of the mitochondrial network, whereas apoptosis-inhibitory members, such as Bcl-2 and Bcl-xL, can antagonize these events. It remains unclear whether CED-9, the worm Bcl-2 relative, can regulate mitochondrial fission/fusion dynamics or the release of proteins from the mitochondrial intermembrane space. Here, we show that CED-9 interacts with Mitofusin-2/fuzzy onions and can promote mitochondrial clustering and dramatic reorganization of mitochondrial networks. Consistent with its ability to neutralize CED-9 function, EGL-1 antagonized CED-9-dependent remodeling of the mitochondrial network. However, CED-9 failed to inhibit mitochondrial cytochrome c release or apoptosis induced by diverse triggers in mammalian cells. These data suggest that the ability to regulate mitochondrial fission/fusion dynamics is an evolutionarily conserved property of the Bcl-2 family.

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Published date: 17 March 2006

Identifiers

Local EPrints ID: 164799
URI: http://eprints.soton.ac.uk/id/eprint/164799
ISSN: 1097-2765
PURE UUID: c64ec1f6-a2ba-4769-b1bb-538addb1aad3

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Date deposited: 04 Oct 2010 14:48
Last modified: 18 Jul 2017 12:28

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Contributors

Author: Petrina Delivani
Author: Colin Adrain
Author: Rebecca C. Taylor
Author: Patrick J. Duriez
Author: Seamus J. Martin

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