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The design of scaffolds for use in tissue engineering. Part 1. Traditional factors

The design of scaffolds for use in tissue engineering. Part 1. Traditional factors
The design of scaffolds for use in tissue engineering. Part 1. Traditional factors
In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.
1076-3279
679-689
Yang, Shoufeng
e0018adf-8123-4a54-b8dd-306c10ca48f1
Leong, Kah-Fai
49483f3f-8f68-4bff-874f-30b364b1b41b
Du, Zhaohui
c9866285-429e-4887-976f-c9c55ecb74b7
Chua, Chee-Kai
8b885b82-4ae1-4c6d-b7d4-2d8501a110ea
Yang, Shoufeng
e0018adf-8123-4a54-b8dd-306c10ca48f1
Leong, Kah-Fai
49483f3f-8f68-4bff-874f-30b364b1b41b
Du, Zhaohui
c9866285-429e-4887-976f-c9c55ecb74b7
Chua, Chee-Kai
8b885b82-4ae1-4c6d-b7d4-2d8501a110ea

Yang, Shoufeng, Leong, Kah-Fai, Du, Zhaohui and Chua, Chee-Kai (2004) The design of scaffolds for use in tissue engineering. Part 1. Traditional factors. Tissue Engineering, 7 (6), 679-689. (PMID:11749726)

Record type: Article

Abstract

In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.

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More information

Published date: 9 July 2004
Organisations: Engineering Mats & Surface Engineerg Gp

Identifiers

Local EPrints ID: 165105
URI: https://eprints.soton.ac.uk/id/eprint/165105
ISSN: 1076-3279
PURE UUID: fc9907fd-d087-4bc0-8db6-f19afde760ab
ORCID for Shoufeng Yang: ORCID iD orcid.org/0000-0002-3888-3211

Catalogue record

Date deposited: 08 Oct 2010 09:25
Last modified: 06 Jun 2018 12:33

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