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Distinct variants at LIN28B influence growth in height from birth to childhood

Widén, Elisabeth, Ripatti, Samuli, Cousminer, Diana L., Surakka, Ida, Lappalainen, Tuuli, Järvelin, Marjo-Riitta, Eriksson, Johan G., Raitakari, Olli, Salomaa, Veikko, Sovio, Ulla, Hartikainen, Anna-Liisa, Pouta, Anneli, McCarthy, Mark I., Osmond, Clive, Kajantie, Eero, Lehtimaki, Terho, Viikari, Jorma, Kahonen, Mika, Tyler-Smith, Chris, Freimer, Nelson, Hirschhorn, Joel N., Peltonen, Leena and Palotie, Aarno (2010) Distinct variants at LIN28B influence growth in height from birth to childhood The American Journal of Human Genetics, 86, (5), pp. 773-782. (doi:10.1016/j.ajhg.2010.03.010). (PMID:20398887).

Record type: Article

Abstract

We have studied the largely unknown genetic underpinnings of height growth by using a unique resource of longitudinal childhood height data available in Finnish population cohorts. After applying GWAS mapping of potential genes influencing pubertal height growth followed by further characterization of the genetic effects on complete postnatal growth trajectories, we have identified strong association between variants near LIN28B and pubertal growth (rs7759938; female p = 4.0 × 10?9, male p = 1.5 × 10?4, combined p = 5.0 × 10?11, n = 5038). Analysis of growth during early puberty confirmed an effect on the timing of the growth spurt. Correlated SNPs have previously been implicated as influencing both adult stature and age at menarche, the same alleles associating with taller height and later age of menarche in other studies as with later pubertal growth here. Additionally, a partially correlated LIN28B SNP, rs314277, has been associated previously with final height. Testing both rs7759938 and rs314277 (pairwise r2 = 0.29) for independent effects on postnatal growth in 8903 subjects indicated that the pubertal timing-associated marker rs7759938 affects prepubertal growth in females (p = 7 × 10?5) and final height in males (p = 5 × 10?4), whereas rs314277 has sex-specific effects on growth (p for interaction = 0.005) that were distinct from those observed at rs7759938. In conclusion, partially correlated variants at LIN28B tag distinctive, complex, and sex-specific height-growth-regulating effects, influencing the entire period of postnatal growth. These findings imply a critical role for LIN28B in the regulation of human growth.

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Published date: 14 May 2010

Identifiers

Local EPrints ID: 165131
URI: http://eprints.soton.ac.uk/id/eprint/165131
ISSN: 0002-9297
PURE UUID: fcacf199-26d5-4e73-83dd-6e5634199567
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 07 Oct 2010 13:40
Last modified: 18 Jul 2017 12:28

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Contributors

Author: Elisabeth Widén
Author: Samuli Ripatti
Author: Diana L. Cousminer
Author: Ida Surakka
Author: Tuuli Lappalainen
Author: Marjo-Riitta Järvelin
Author: Johan G. Eriksson
Author: Olli Raitakari
Author: Veikko Salomaa
Author: Ulla Sovio
Author: Anna-Liisa Hartikainen
Author: Anneli Pouta
Author: Mark I. McCarthy
Author: Clive Osmond ORCID iD
Author: Eero Kajantie
Author: Terho Lehtimaki
Author: Jorma Viikari
Author: Mika Kahonen
Author: Chris Tyler-Smith
Author: Nelson Freimer
Author: Joel N. Hirschhorn
Author: Leena Peltonen
Author: Aarno Palotie

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