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The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood

The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood
The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood
Aims: Low birth weight and low placental weight predict later coronary heart disease and hypertension. This has led to the hypothesis that these diseases are initiated by foetal programming, the process by which foetal malnutrition leads to permanent changes in the body in ways that lead to chronic disease in later life. Here we examine the association between body and placental size at birth and later chronic heart failure.

Methods and results: We identified 187 patients taking medications for chronic heart failure in a birth cohort of 13 345 people born in Helsinki, Finland during 1934–44. Chronic heart failure was associated with a small placental surface area. In people born with a placental area less than 225 cm2, the odds ratio for chronic heart failure was 1.7 (1.1–2.5), compared with people born with a placental area greater than 295 cm2. The risk of heart failure was further increased by rapid gain in body mass index after the age of 2 years, a path of growth known to be linked to insulin resistance in later life. In a simultaneous regression, low body mass index at 2 years and high body mass index at 11 years were each associated with chronic heart failure (P = 0.008 and 0.001, respectively).

Conclusion: Chronic heart failure in adult life may be initiated by impaired
heart failure, placenta, type 2 diabetes, maternal stature, childhood growth
1388-9842
819-825
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Gelow, Jill
d3ca4c3a-7ce0-4282-867c-01a3bd0a189b
Thornburg, Kent
b407f955-ba0d-458b-8e16-5c536ab12605
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Gelow, Jill
d3ca4c3a-7ce0-4282-867c-01a3bd0a189b
Thornburg, Kent
b407f955-ba0d-458b-8e16-5c536ab12605
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac

Barker, David J.P., Gelow, Jill, Thornburg, Kent, Osmond, Clive, Kajantie, Eero and Eriksson, Johan G. (2010) The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood. European Journal of Heart Failure, 12 (8), 819-825. (doi:10.1093/eurjhf/hfq069). (PMID:20504866)

Record type: Article

Abstract

Aims: Low birth weight and low placental weight predict later coronary heart disease and hypertension. This has led to the hypothesis that these diseases are initiated by foetal programming, the process by which foetal malnutrition leads to permanent changes in the body in ways that lead to chronic disease in later life. Here we examine the association between body and placental size at birth and later chronic heart failure.

Methods and results: We identified 187 patients taking medications for chronic heart failure in a birth cohort of 13 345 people born in Helsinki, Finland during 1934–44. Chronic heart failure was associated with a small placental surface area. In people born with a placental area less than 225 cm2, the odds ratio for chronic heart failure was 1.7 (1.1–2.5), compared with people born with a placental area greater than 295 cm2. The risk of heart failure was further increased by rapid gain in body mass index after the age of 2 years, a path of growth known to be linked to insulin resistance in later life. In a simultaneous regression, low body mass index at 2 years and high body mass index at 11 years were each associated with chronic heart failure (P = 0.008 and 0.001, respectively).

Conclusion: Chronic heart failure in adult life may be initiated by impaired

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More information

Published date: 26 May 2010
Keywords: heart failure, placenta, type 2 diabetes, maternal stature, childhood growth

Identifiers

Local EPrints ID: 165133
URI: https://eprints.soton.ac.uk/id/eprint/165133
ISSN: 1388-9842
PURE UUID: 867691ad-b06e-4487-911e-4216a34e88fc
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 07 Oct 2010 14:16
Last modified: 20 Jul 2019 01:18

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Contributors

Author: David J.P. Barker
Author: Jill Gelow
Author: Kent Thornburg
Author: Clive Osmond ORCID iD
Author: Eero Kajantie
Author: Johan G. Eriksson

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