Impact of integrated PET/CT in the staging of oesophageal cancer: a UK population-based cohort study
Impact of integrated PET/CT in the staging of oesophageal cancer: a UK population-based cohort study
Aim: to document the impact of integrated positron-emission tomography and computed tomography (PET/CT) on the management of a cohort of UK patients undergoing PET/CT as part of their staging investigations for potentially curable oesophageal cancer.
Materials and methods: a multicentre, prospective study of newly diagnosed patients with oesophageal cancer undergoing PET/CT was set up across five cancer networks covering a total population of 6.6 million. Data were prospectively collected for cases diagnosed between 1 November 2006 and 31 October 2007.
Results: one hundred and ninety-one patients underwent PET/CT, with 31 (16%) positive for possible metastatic disease. Amongst the 31 positive examinations, 18 (9.4%) were confirmed to have metastatic disease, and 13 (6.5%) patients had no subsequent evidence of metastatic disease, although in three (1.6%) of these a second previously unsuspected pathology was diagnosed. Two patients had false-negative PET/CT and were found to have metastatic disease. The results of the PET/CT examination down-staged 10 (5%) patients thought to have coeliac/M1a node involvement on CT. Fifteen of 110 (13%) patients with stage 3 or 4 disease at CT and endoscopic ultrasound (EUS) had confirmed metastatic disease at PET/CT, compared with none of 18 with stage 2b, three of 52 (6%) with stage 2a, and none of 10 with stage 1 disease.
Conclusion: this study confirms the role of PET/CT in a multicentre UK setting in the management of patients with potentially curable carcinoma of the oesophagus, improving the accuracy of pre-treatment staging compared with CT and EUS alone. Early tumours infrequently show evidence of metastasis on PET/CT, although further data are required to confidently determine the stage of tumours where PET/CT has no additional value
699-705
Noble, F.
4f14574c-28f2-4e04-bd95-f53c7649e1fa
Bailey, D.
2b9988b1-d7f4-43a5-87a6-f61f7b287f32
Tung, K.
f29f20cf-024c-49ae-b654-11972081e3bb
Byrne, J.P.
f4396d91-f3b0-4b47-ba9c-a3db107db533
1 July 2009
Noble, F.
4f14574c-28f2-4e04-bd95-f53c7649e1fa
Bailey, D.
2b9988b1-d7f4-43a5-87a6-f61f7b287f32
Tung, K.
f29f20cf-024c-49ae-b654-11972081e3bb
Byrne, J.P.
f4396d91-f3b0-4b47-ba9c-a3db107db533
Noble, F., Bailey, D., Tung, K. and Byrne, J.P.
(2009)
Impact of integrated PET/CT in the staging of oesophageal cancer: a UK population-based cohort study.
Clinical Radiology, 64 (7), .
(doi:10.1016/j.crad.2009.03.003).
(PMID:19520214)
Abstract
Aim: to document the impact of integrated positron-emission tomography and computed tomography (PET/CT) on the management of a cohort of UK patients undergoing PET/CT as part of their staging investigations for potentially curable oesophageal cancer.
Materials and methods: a multicentre, prospective study of newly diagnosed patients with oesophageal cancer undergoing PET/CT was set up across five cancer networks covering a total population of 6.6 million. Data were prospectively collected for cases diagnosed between 1 November 2006 and 31 October 2007.
Results: one hundred and ninety-one patients underwent PET/CT, with 31 (16%) positive for possible metastatic disease. Amongst the 31 positive examinations, 18 (9.4%) were confirmed to have metastatic disease, and 13 (6.5%) patients had no subsequent evidence of metastatic disease, although in three (1.6%) of these a second previously unsuspected pathology was diagnosed. Two patients had false-negative PET/CT and were found to have metastatic disease. The results of the PET/CT examination down-staged 10 (5%) patients thought to have coeliac/M1a node involvement on CT. Fifteen of 110 (13%) patients with stage 3 or 4 disease at CT and endoscopic ultrasound (EUS) had confirmed metastatic disease at PET/CT, compared with none of 18 with stage 2b, three of 52 (6%) with stage 2a, and none of 10 with stage 1 disease.
Conclusion: this study confirms the role of PET/CT in a multicentre UK setting in the management of patients with potentially curable carcinoma of the oesophagus, improving the accuracy of pre-treatment staging compared with CT and EUS alone. Early tumours infrequently show evidence of metastasis on PET/CT, although further data are required to confidently determine the stage of tumours where PET/CT has no additional value
Text
PETCT_2009.pdf
- Accepted Manuscript
More information
Published date: 1 July 2009
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 165195
URI: http://eprints.soton.ac.uk/id/eprint/165195
ISSN: 0009-9260
PURE UUID: 801429ae-f899-4da7-8d1e-58b8b3fee307
Catalogue record
Date deposited: 08 Oct 2010 13:37
Last modified: 14 Mar 2024 02:10
Export record
Altmetrics
Contributors
Author:
F. Noble
Author:
D. Bailey
Author:
K. Tung
Author:
J.P. Byrne
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics