Objectively measured physical capability levels and mortality: systematic review and meta-analysis
Objectively measured physical capability levels and mortality: systematic review and meta-analysis
Objective: To do a quantitative systematic review, including published and unpublished data, examining the associations between individual objective measures of physical capability (grip strength, walking speed, chair rising, and standing balance times) and mortality in community dwelling populations.
Design: Systematic review and meta-analysis.
Data sources: Relevant studies published by May 2009 identified through literature searches using Embase (from 1980) and Medline (from 1950) and manual searching of reference lists; unpublished results were obtained from study investigators.
Study selection: Eligible observational studies were those done in community dwelling people of any age that examined the association of at least one of the specified measures of physical capability (grip strength, walking speed, chair rises, or standing balance) with mortality.
Data synthesis: Effect estimates obtained were pooled by using random effects meta-analysis models with heterogeneity between studies investigated.
Results: Although heterogeneity was detected, consistent evidence was found of associations between all four measures of physical capability and mortality; those people who performed less well in these tests were found to be at higher risk of all cause mortality. For example, the summary hazard ratio for mortality comparing the weakest with the strongest quarter of grip strength (14 studies, 53?476 participants) was 1.67 (95% confidence interval 1.45 to 1.93) after adjustment for age, sex, and body size (I2=84.0%, 95% confidence interval 74% to 90%; P from Q statistic <0.001). The summary hazard ratio for mortality comparing the slowest with the fastest quarter of walking speed (five studies, 14?692 participants) was 2.87 (2.22 to 3.72) (I2=25.2%, 0% to 70%; P=0.25) after similar adjustments. Whereas studies of the associations of walking speed, chair rising, and standing balance with mortality have only been done in older populations (average age over 70 years), the association of grip strength with mortality was also found in younger populations (five studies had an average age under 60 years).
Conclusions: Objective measures of physical capability are predictors of all cause mortality in older community dwelling populations. Such measures may therefore provide useful tools for identifying older people at higher risk of death.
c4467
Cooper, Rachel
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Kuh, Diana
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Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Sayer, A.A.
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Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
Wills, A.K.
a49cf0bc-8fe1-4672-8ff2-da46760d2059
9 September 2010
Cooper, Rachel
24a4a55a-ccc1-4961-9b76-b89aa4eb2fdf
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
Wills, A.K.
a49cf0bc-8fe1-4672-8ff2-da46760d2059
Cooper, Rachel, Kuh, Diana, Hardy, Rebecca, Sayer, A.A., Gale, C.R., Syddall, H. and Wills, A.K.
(2010)
Objectively measured physical capability levels and mortality: systematic review and meta-analysis.
BMJ, 341, .
(doi:10.1136/bmj.c4467).
(PMID:20829298)
Abstract
Objective: To do a quantitative systematic review, including published and unpublished data, examining the associations between individual objective measures of physical capability (grip strength, walking speed, chair rising, and standing balance times) and mortality in community dwelling populations.
Design: Systematic review and meta-analysis.
Data sources: Relevant studies published by May 2009 identified through literature searches using Embase (from 1980) and Medline (from 1950) and manual searching of reference lists; unpublished results were obtained from study investigators.
Study selection: Eligible observational studies were those done in community dwelling people of any age that examined the association of at least one of the specified measures of physical capability (grip strength, walking speed, chair rises, or standing balance) with mortality.
Data synthesis: Effect estimates obtained were pooled by using random effects meta-analysis models with heterogeneity between studies investigated.
Results: Although heterogeneity was detected, consistent evidence was found of associations between all four measures of physical capability and mortality; those people who performed less well in these tests were found to be at higher risk of all cause mortality. For example, the summary hazard ratio for mortality comparing the weakest with the strongest quarter of grip strength (14 studies, 53?476 participants) was 1.67 (95% confidence interval 1.45 to 1.93) after adjustment for age, sex, and body size (I2=84.0%, 95% confidence interval 74% to 90%; P from Q statistic <0.001). The summary hazard ratio for mortality comparing the slowest with the fastest quarter of walking speed (five studies, 14?692 participants) was 2.87 (2.22 to 3.72) (I2=25.2%, 0% to 70%; P=0.25) after similar adjustments. Whereas studies of the associations of walking speed, chair rising, and standing balance with mortality have only been done in older populations (average age over 70 years), the association of grip strength with mortality was also found in younger populations (five studies had an average age under 60 years).
Conclusions: Objective measures of physical capability are predictors of all cause mortality in older community dwelling populations. Such measures may therefore provide useful tools for identifying older people at higher risk of death.
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Published date: 9 September 2010
Organisations:
Medicine
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Local EPrints ID: 165237
URI: http://eprints.soton.ac.uk/id/eprint/165237
ISSN: 0959-8138
PURE UUID: 206f8b1c-bba5-4245-954d-e108e73cab3b
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Date deposited: 11 Oct 2010 09:05
Last modified: 14 Mar 2024 02:41
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Author:
Rachel Cooper
Author:
Diana Kuh
Author:
Rebecca Hardy
Author:
A.A. Sayer
Author:
A.K. Wills
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