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Childhood cognitive ability: relationship to gestational diabetes mellitus in India

Childhood cognitive ability: relationship to gestational diabetes mellitus in India
Childhood cognitive ability: relationship to gestational diabetes mellitus in India
Aims/hypothesis: Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.

Methods: During 1997 to 1998 maternal GDM status was assessed by OGTT at 30?±?2 weeks of gestation. Between 2007 and 2008, at a mean age of 9.7 years, 515 children (32 offspring of GDM mothers [ODM]; 483 offspring of non-GDM mothers [controls]) from the Mysore Parthenon birth cohort underwent cognitive function assessment using tests from the Kaufman Assessment Battery for Children—Second Edition and additional tests measuring learning, long-term storage/retrieval, short-term memory, reasoning, attention and concentration, and visuo-spatial and verbal abilities.

Results: Compared with controls, ODM scored higher in tests for learning, long-term retrieval/storage (p?=?0.008), reasoning (p?=?0.02), verbal ability (p?=?0.01), and attention and concentration (p?=?0.003). In multiple regression, adjusted for the child’s age, sex, gestation, neonatal weight and head circumference, maternal age, parity and BMI, and the parent’s socioeconomic status, education and rural/urban residence, this difference remained significant only for learning, long-term retrieval/storage (??=?0.4 SD (95% CI 0.01–0.75); p?=?0.04) and verbal ability (??=?0.5 SD (95% CI 0.09–0.83); p?=?0.02), and not with other test scores.

Conclusions/interpretation: In this population of healthy Indian children, there was no evidence of lower cognitive ability in ODM. In fact some cognitive scores were higher in ODM.
children, cognitive function, gestational diabetes mellitus, india
0012-186X
2134-2138
Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Srinivasan, K.
a5367aa3-c40e-4c3c-825e-2d150a3e40c5
Kurpad, A.V.
35ccfb0b-44b2-4dfc-969c-15160007f9c6
Muthayya, S
d7ec257d-923b-4050-827b-eb168bedbc70
Hill, J.C.
418c7f77-f207-4e8d-98fa-7dbe8b2a02c1
Kiran, K.N.
5b9dd737-2099-4a8b-89a0-d737f8e0b0a5
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18
Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Srinivasan, K.
a5367aa3-c40e-4c3c-825e-2d150a3e40c5
Kurpad, A.V.
35ccfb0b-44b2-4dfc-969c-15160007f9c6
Muthayya, S
d7ec257d-923b-4050-827b-eb168bedbc70
Hill, J.C.
418c7f77-f207-4e8d-98fa-7dbe8b2a02c1
Kiran, K.N.
5b9dd737-2099-4a8b-89a0-d737f8e0b0a5
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18

Veena, S.R., Krishnaveni, G.V., Srinivasan, K., Kurpad, A.V., Muthayya, S, Hill, J.C., Kiran, K.N. and Fall, C.H. (2010) Childhood cognitive ability: relationship to gestational diabetes mellitus in India. Diabetologia, 53 (10), 2134-2138. (doi:10.1007/s00125-010-1847-0). (PMID:20614102)

Record type: Article

Abstract

Aims/hypothesis: Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.

Methods: During 1997 to 1998 maternal GDM status was assessed by OGTT at 30?±?2 weeks of gestation. Between 2007 and 2008, at a mean age of 9.7 years, 515 children (32 offspring of GDM mothers [ODM]; 483 offspring of non-GDM mothers [controls]) from the Mysore Parthenon birth cohort underwent cognitive function assessment using tests from the Kaufman Assessment Battery for Children—Second Edition and additional tests measuring learning, long-term storage/retrieval, short-term memory, reasoning, attention and concentration, and visuo-spatial and verbal abilities.

Results: Compared with controls, ODM scored higher in tests for learning, long-term retrieval/storage (p?=?0.008), reasoning (p?=?0.02), verbal ability (p?=?0.01), and attention and concentration (p?=?0.003). In multiple regression, adjusted for the child’s age, sex, gestation, neonatal weight and head circumference, maternal age, parity and BMI, and the parent’s socioeconomic status, education and rural/urban residence, this difference remained significant only for learning, long-term retrieval/storage (??=?0.4 SD (95% CI 0.01–0.75); p?=?0.04) and verbal ability (??=?0.5 SD (95% CI 0.09–0.83); p?=?0.02), and not with other test scores.

Conclusions/interpretation: In this population of healthy Indian children, there was no evidence of lower cognitive ability in ODM. In fact some cognitive scores were higher in ODM.

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More information

Published date: October 2010
Keywords: children, cognitive function, gestational diabetes mellitus, india

Identifiers

Local EPrints ID: 165453
URI: http://eprints.soton.ac.uk/id/eprint/165453
ISSN: 0012-186X
PURE UUID: add1cb5c-d8c9-4e2f-947e-d8c372981720
ORCID for C.H. Fall: ORCID iD orcid.org/0000-0003-4402-5552

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Date deposited: 12 Oct 2010 15:22
Last modified: 14 Mar 2024 02:34

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Contributors

Author: S.R. Veena
Author: G.V. Krishnaveni
Author: K. Srinivasan
Author: A.V. Kurpad
Author: S Muthayya
Author: J.C. Hill
Author: K.N. Kiran
Author: C.H. Fall ORCID iD

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