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Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women

Currie, James, Ramsbottom, Roger, Ludlow, Helen, Nevill, Alan and Gilder, Michael (2009) Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women Neuroscience Letters, 452, (2), pp. 152-155. (doi:10.1016/j.neulet.2008.12.043). (PMID:19133315).

Record type: Article


Short episodes of high intensity exercise transiently increase serum levels of BDNF in humans, but serum levels of BDNF at rest appear to be lower in more physically active humans with greater levels of energy expenditure. The relationship between serum BDNF concentration, cardio-respiratory fitness (Åstrand–Rhyming test estimated VO2 max) and volume of long-term, regular exercise and sporting activity (Baecke Habitual Physical Activity Index) was investigated in 44 men and women between the age range of 18–57 years. In this group an inverse relationship between resting serum BDNF concentration and measures of both estimated VO2 max (r = ?0.352; P < 0.05) and long-term sporting activity (r = ?0.428, P < 0.01) was found. These results indicate that increased levels of cardio-respiratory fitness and habitual exercise are associated with lower resting levels of serum BDNF in healthy humans. This is the first study to demonstrate an inverse relationship between a physiological estimate of cardio-respiratory fitness and serum BDNF.

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Published date: 20 February 2009
Keywords: bdnf, estimated vo2 max, physical activity, human


Local EPrints ID: 165935
ISSN: 0304-3940
PURE UUID: 251d6874-5d02-409f-9c3d-156a8af60e5c

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Date deposited: 20 Oct 2010 10:56
Last modified: 18 Jul 2017 12:26

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Author: James Currie
Author: Roger Ramsbottom
Author: Helen Ludlow
Author: Alan Nevill
Author: Michael Gilder

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